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Mouse Anti-HHIP (AA 21-120) Recombinant Antibody (CBFYH-1063) (CBMAB-H2007-FY)

This product is mouse antibody that recognizes HHIP. The antibody CBFYH-1063 can be used for immunoassay techniques such as: ELISA, IHC-P, IP, WB.
See all HHIP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1063
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC-P, IP, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: GDAKFGERNE GSGARRRRCL NGNPPKRLKR RDRRMMSQLE LLSGGEMLCG GFYPRLSCCL RSDSPGLGRL ENKIFSVTNN TECGKLLEEI KCALCSPHSQ
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 21-120

Target

Full Name
hedgehog interacting protein
Introduction
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.
Entrez Gene ID
64399
UniProt ID
Q96QV1
Alternative Names
Hedgehog Interacting Protein; Hedgehog-Interacting Protein; HIP
Function
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Biological Process
Dorsal/ventral pattern formation Source: Ensembl
Epithelial tube branching involved in lung morphogenesis Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of signal transduction Source: UniProtKB
Negative regulation of smoothened signaling pathway Source: BHF-UCL
Neuroblast proliferation Source: Ensembl
Regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
Signal transduction Source: Ensembl
Skeletal system morphogenesis Source: BHF-UCL
Cellular Location
Cell membrane; Secreted. The last 22 C-terminal amino acids may participate in cell membrane attachment.
Isoform 2: Cytoplasm

Caligiuri, S. P., Howe, W. M., Wills, L., Smith, A. C., Lei, Y., Bali, P., ... & Kenny, P. J. (2022). Hedgehog-interacting protein acts in the habenula to regulate nicotine intake. Proceedings of the National Academy of Sciences, 119(46), e2209870119.

Griffiths, S. C., Schwab, R. A., El Omari, K., Bishop, B., Iverson, E. J., Malinauskas, T., ... & Siebold, C. (2021). Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nature communications, 12(1), 7171.

Li, P., Zhang, X., Murphy, A. J., Costa, M., Zhao, X., & Sun, H. (2021). Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells. Carcinogenesis, 42(1), 136-147.

Li, Y., Zhang, L., Polverino, F., Guo, F., Hao, Y., Lao, T., ... & Zhou, X. (2021). Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells. Scientific reports, 11(1), 9074.

Chou, H. W., Hung, H. C., Lin, C. H., Lin, A. C., Du, Y. F., Cheng, K. P., ... & Ou, H. Y. (2021). The serum concentrations of hedgehog-interacting protein, a novel biomarker, were decreased in overweight or obese subjects. Journal of Clinical Medicine, 10(4), 742.

Miyata, K. N., Zhao, X. P., Chang, S. Y., Liao, M. C., Lo, C. S., Chenier, I., ... & Zhang, S. L. (2020). Increased urinary excretion of hedgehog interacting protein (uHhip) in early diabetic kidney disease. Translational Research, 217, 1-10.

Lin, A. C., Hung, H. C., Chen, Y. W., Cheng, K. P., Li, C. H., Lin, C. H., ... & Ou, H. Y. (2019). Elevated Hedgehog-interacting protein levels in subjects with prediabetes and type 2 diabetes. Journal of Clinical Medicine, 8(10), 1635.

Nchienzia, H., Liao, M. C., Zhao, X. P., Chang, S. Y., Lo, C. S., Chenier, I., ... & Zhang, S. L. (2019). Hedgehog interacting protein (Hhip) regulates insulin secretion in mice fed high fat diets. Scientific Reports, 9(1), 11183.

Zhao, X. P., Chang, S. Y., Liao, M. C., Lo, C. S., Chenier, I., Luo, H., ... & Zhang, S. L. (2018). Hedgehog interacting protein promotes fibrosis and apoptosis in glomerular endothelial cells in murine diabetes. Scientific Reports, 8(1), 5958.

Sun, H., juan Ni, S., Ye, M., Weng, W., Zhang, Q., Zhang, M., ... & Sheng, W. (2018). Hedgehog interacting protein 1 is a prognostic marker and suppresses cell metastasis in gastric cancer. Journal of Cancer, 9(24), 4642.

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For research use only. Not intended for any clinical use.

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