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Mouse Anti-HIP1 Recombinant Antibody (CBFYH-1115) (CBMAB-H2068-FY)

This product is mouse antibody that recognizes HIP1. The antibody CBFYH-1115 can be used for immunoassay techniques such as: WB.
See all HIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1115
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Human HIP1r-TALIN Homology Region
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Huntingtin Interacting Protein 1
Introduction
The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
UniProt ID
Alternative Names
Huntingtin Interacting Protein 1; Huntingtin-Interacting Protein I; HIP-I; Huntingtin-Interacting Protein 1; SHONgamma; SHONbeta; ILWEQ; HIP-1; SHON
Function
Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126).

Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity).

Regulates presynaptic nerve terminal activity (By similarity).

Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218).

May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801).

Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715).

May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715).

May play a functional role in the cell filament networks (PubMed:18790740).

May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454).
Biological Process
Actin filament organization Source: GO_Central
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
Apoptotic process Source: MGI
Apoptotic signaling pathway Source: UniProtKB
Cell differentiation Source: UniProtKB-KW
Clathrin coat assembly Source: UniProtKB
Clathrin-dependent endocytosis Source: InterPro
Endocytosis Source: GO_Central
Neurotransmitter receptor transport Source: ParkinsonsUK-UCL
Positive regulation of epidermal growth factor receptor signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of platelet-derived growth factor receptor-beta signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of protein kinase B signaling Source: ParkinsonsUK-UCL
Positive regulation of receptor-mediated endocytosis Source: UniProtKB
Protein stabilization Source: ParkinsonsUK-UCL
Regulation of apoptotic process Source: MGI
Regulation of endocytosis Source: ParkinsonsUK-UCL
Cellular Location
Nucleus; Cytoplasm; Endomembrane system; Clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
Involvement in disease
A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134).

Prasad, P., Chongtham, J., Tripathi, S. C., Ganguly, N. K., Mittal, S. A., & Srivastava, T. (2023). Huntingtin Interacting Protein-1 expression is regulated via HIF2 axis in Lung Adenocarcinoma. bioRxiv, 2023-03.

Lacombe, L., Hovington, H., Brisson, H., Mehdi, S., Beillevaire, D., Émond, J. P., ... & Lévesque, E. (2023). UGT2B28 accelerates prostate cancer progression through stabilization of the endocytic adaptor protein HIP1 regulating AR and EGFR pathways. Cancer Letters, 553, 215994.

Surbhi, Goel, A., Chaturvedi, V., Verma, S., Rawat, S., Ganguly, N. K., & Mittal, S. A. (2022). Huntingtin Interacting Protein 1 (HIP1) autoantibodies as a novel potential surrogate marker for Rheumatoid Arthritis: Pilot Study. medRxiv, 2022-09.

Tamta, S., Goel, A., Chaturvedi, V., Verma, S., Rawat, S., Ganguly, N. K., & Mittal, S. A. (2022). Huntingtin Interacting Protein 1 (HIP1) autoantibodies as a novel potential surrogate marker for Rheumatoid Arthritis: Pilot Study.

Kang, J., Deng, Q. M., Peng, K. C., Li, P., Zhu, B. T., Wang, P., ... & Yang, J. J. (2022). Clinicopathological features and resistance mechanisms in HIP1‐ALK‐rearranged lung cancer: A multicenter study. Genes, Chromosomes and Cancer, 61(4), 177-186.

Murakami, T., Matsuura, R., Chutiwitoonchai, N., Takei, M., & Aida, Y. (2021). Huntingtin-Interacting Protein 1 Promotes Vpr-Induced G2 Arrest and HIV-1 Infection in Macrophages. Viruses, 13(11), 2308.

Sun, Y., Zhou, Y., Xia, J., Wen, M., Wang, X., Zhang, J., ... & Jiang, T. (2021). Abnormally high HIP1 expression is associated with metastatic behaviors and poor prognosis in ESCC. Oncology Letters, 21(2), 1-1.

Laragione, T., Brenner, M., Lahiri, A., Gao, E., Harris, C., & Gulko, P. S. (2018). Huntingtin-interacting protein 1 (HIP1) regulates arthritis severity and synovial fibroblast invasiveness by altering PDGFR and Rac1 signalling. Annals of the rheumatic diseases, 77(11), 1627-1635.

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For research use only. Not intended for any clinical use.

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