Mouse Anti-HIP1 Recombinant Antibody (CBFYH-1115) (CBMAB-H2068-FY)

Name: Mouse Anti-HIP1 Recombinant Antibody (CBFYH-1115)
SKU: CBMAB-H2068-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYH-1115

Application

Immunogen

Human HIP1r-TALIN Homology Region

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Huntingtin Interacting Protein 1

Introduction

The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

3092

UniProt ID

O00291

Alternative Names

Huntingtin Interacting Protein 1; Huntingtin-Interacting Protein I; HIP-I; Huntingtin-Interacting Protein 1; SHONgamma; SHONbeta; ILWEQ; HIP-1; SHON

Function

Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126).

Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity).

Regulates presynaptic nerve terminal activity (By similarity).

Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218).

May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801).

Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715).

May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715).

May play a functional role in the cell filament networks (PubMed:18790740).

May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454).

Biological Process

Actin filament organization Source: GO_Central
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
Apoptotic process Source: MGI
Apoptotic signaling pathway Source: UniProtKB
Cell differentiation Source: UniProtKB-KW
Clathrin coat assembly Source: UniProtKB
Clathrin-dependent endocytosis Source: InterPro
Endocytosis Source: GO_Central
Neurotransmitter receptor transport Source: ParkinsonsUK-UCL
Positive regulation of epidermal growth factor receptor signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of platelet-derived growth factor receptor-beta signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of protein kinase B signaling Source: ParkinsonsUK-UCL
Positive regulation of receptor-mediated endocytosis Source: UniProtKB
Protein stabilization Source: ParkinsonsUK-UCL
Regulation of apoptotic process Source: MGI
Regulation of endocytosis Source: ParkinsonsUK-UCL

Cellular Location

Nucleus; Cytoplasm; Endomembrane system; Clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.

Involvement in disease

A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134).

Prasad, P., Chongtham, J., Tripathi, S. C., Ganguly, N. K., Mittal, S. A., & Srivastava, T. (2023). Huntingtin Interacting Protein-1 expression is regulated via HIF2 axis in Lung Adenocarcinoma. bioRxiv, 2023-03.

Lacombe, L., Hovington, H., Brisson, H., Mehdi, S., Beillevaire, D., Émond, J. P., ... & Lévesque, E. (2023). UGT2B28 accelerates prostate cancer progression through stabilization of the endocytic adaptor protein HIP1 regulating AR and EGFR pathways. Cancer Letters, 553, 215994.

Surbhi, Goel, A., Chaturvedi, V., Verma, S., Rawat, S., Ganguly, N. K., & Mittal, S. A. (2022). Huntingtin Interacting Protein 1 (HIP1) autoantibodies as a novel potential surrogate marker for Rheumatoid Arthritis: Pilot Study. medRxiv, 2022-09.

Tamta, S., Goel, A., Chaturvedi, V., Verma, S., Rawat, S., Ganguly, N. K., & Mittal, S. A. (2022). Huntingtin Interacting Protein 1 (HIP1) autoantibodies as a novel potential surrogate marker for Rheumatoid Arthritis: Pilot Study.

Kang, J., Deng, Q. M., Peng, K. C., Li, P., Zhu, B. T., Wang, P., ... & Yang, J. J. (2022). Clinicopathological features and resistance mechanisms in HIP1‐ALK‐rearranged lung cancer: A multicenter study. Genes, Chromosomes and Cancer, 61(4), 177-186.

Murakami, T., Matsuura, R., Chutiwitoonchai, N., Takei, M., & Aida, Y. (2021). Huntingtin-Interacting Protein 1 Promotes Vpr-Induced G2 Arrest and HIV-1 Infection in Macrophages. Viruses, 13(11), 2308.

Sun, Y., Zhou, Y., Xia, J., Wen, M., Wang, X., Zhang, J., ... & Jiang, T. (2021). Abnormally high HIP1 expression is associated with metastatic behaviors and poor prognosis in ESCC. Oncology Letters, 21(2), 1-1.

Laragione, T., Brenner, M., Lahiri, A., Gao, E., Harris, C., & Gulko, P. S. (2018). Huntingtin-interacting protein 1 (HIP1) regulates arthritis severity and synovial fibroblast invasiveness by altering PDGFR and Rac1 signalling. Annals of the rheumatic diseases, 77(11), 1627-1635.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

HIP1 Matched Antibody Pair (540) (CAT#: APMAB-540LY)

HIP1 Matched Antibody Pair (541) (CAT#: APMAB-541LY)

HIP1 Matched Antibody Pair (542) (CAT#: APMAB-542LY)

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HIP1 Matched Antibody Pair (541) (CAT#: APMAB-541LY)

Mouse Anti-HIP1 Monoclonal Antibody (4B10) (CAT#: CBMAB-1349-YC)

Mouse Anti-HIP1 Recombinant Antibody (1B11) (CAT#: CBMAB-1577-CN)

HIP1 Matched Antibody Pair (542) (CAT#: APMAB-542LY)

Mouse Anti-HIP1 (AA 928-1038) Recombinant Antibody (CBFYH-1117) (CAT#: CBMAB-H2070-FY)

Isotype control

For research use only. Not intended for any clinical use.

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