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Mouse Anti-HLA-DQA1 Recombinant Antibody (CBFYH-1353) (CBMAB-H0376-FY)

This product is mouse antibody that recognizes HLA-DQA1. The antibody CBFYH-1353 can be used for immunoassay techniques such as: FC, IF.
See all HLA-DQA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1353
Antibody Isotype
IgG2a
Application
FC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 1% BSA
Preservative
0.09% Sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
major histocompatibility complex, class II, DQ alpha 1
Introduction
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
Entrez Gene ID
3117
UniProt ID
P01909
Alternative Names
Major Histocompatibility Complex, Class II, DQ Alpha 1; MHC Class II DQA1; DC-1 Alpha Chain; DC-Alpha; HLA-DCA; HLA Class II Histocompatibility Antigen, DQ Alpha 1 Chain
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Cellular Location
Lysosome membrane; Endosome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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