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Rabbit Anti-HNRNPA0 Recombinant Antibody (D26A2) (CBMAB-CP1054-LY)

The product is antibody recognizes HNRNPA0. The antibody D26A2 immunoassay techniques such as: WB,IP.
See all HNRNPA0 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D26A2
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala152 of human hnRNP A0 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Heterogeneous Nuclear Ribonucleoprotein A0
Introduction
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human10949
Mouse77134
Rat498696
UniProt ID
HumanQ13151
MouseQ9CX86
RatF1M3H8
Alternative Names
Heterogeneous Nuclear Ribonucleoprotein A0; HnRNP A0; HNRPA0; HnRNA Binding Protein;
Function
mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.
Biological Process
3'-UTR-mediated mRNA stabilization Source: UniProtKB
Inflammatory response Source: UniProtKB
mRNA processing Source: ProtInc
Response to lipopolysaccharide Source: UniProtKB
Cellular Location
Nucleus. Component of ribonucleosomes.
PTM
Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.
Arg-291 is dimethylated, probably to asymmetric dimethylarginine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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