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Rabbit Anti-HNRNPA0 Recombinant Antibody (D8A3) (CBMAB-H2613-FY)

This product is rabbit antibody that recognizes HNRNPA0. The antibody D8A3 can be used for immunoassay techniques such as: WB, IP, IF, FC.
See all HNRNPA0 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D8A3
Antibody Isotype
IgG
Application
WB, IP, IF, FC

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Heterogeneous Nuclear Ribonucleoprotein A0
Introduction
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus.
Entrez Gene ID
Human10949
Mouse77134
Rat498696
Monkey713181
UniProt ID
HumanQ13151
MouseQ9CX86
RatF1M3H8
MonkeyA0A0D9S9G6
Alternative Names
Heterogeneous Nuclear Ribonucleoprotein A0; HnRNP A0; HNRPA0; HnRNA Binding Protein
Function
mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.
Biological Process
3'-UTR-mediated mRNA stabilization Source: UniProtKB
Inflammatory response Source: UniProtKB
mRNA processing Source: ProtInc
Response to lipopolysaccharide Source: UniProtKB
Cellular Location
Nucleus. Component of ribonucleosomes.
PTM
Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.
Arg-291 is dimethylated, probably to asymmetric dimethylarginine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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