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Mouse Anti-HNRNPM (AA 17-113) Recombinant Antibody (CBFYH-1673) (CBMAB-H2680-FY)

This product is mouse antibody that recognizes HNRNPM. The antibody CBFYH-1673 can be used for immunoassay techniques such as: WB.
See all HNRNPM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1673
Antibody Isotype
IgG2b, κ
Application
WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 17-113

Target

Full Name
heterogeneous nuclear ribonucleoprotein M
Introduction
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
UniProt ID
Alternative Names
Heterogeneous Nuclear Ribonucleoprotein M; CEA Receptor; HnRNP M; HNRPM; NAGR1; Heterogenous Nuclear Ribonucleoprotein M4; N-Acetylglucosamine Receptor 1
Function
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
Biological Process
Alternative mRNA splicing, via spliceosome Source: BHF-UCL
mRNA splicing, via spliceosome Source: UniProtKB
Regulation of mRNA stability involved in response to oxidative stress Source: GO_Central
Cellular Location
Nucleolus
PTM
Sumoylated.

Zhu, G. Q., Wang, Y., Wang, B., Liu, W. R., Dong, S. S., Chen, E. B., ... & Dai, Z. (2022). Targeting HNRNPM inhibits cancer stemness and enhances antitumor immunity in Wnt-activated hepatocellular carcinoma. Cellular and Molecular Gastroenterology and Hepatology, 13(5), 1413-1447.

Kamo, M., Ito, M., Toma, T., Gotoh, H., Shimozono, R., Nakagawa, R., ... & Fujita, M. (2021). Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M. Bioorganic Chemistry, 107, 104627.

Wang, X., Li, J., Bian, X., Wu, C., Hua, J., Chang, S., ... & Lin, W. (2021). CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer. Proceedings of the National Academy of Sciences, 118(33), e2012881118.

Ho, J. S., Di Tullio, F., Schwarz, M., Low, D., Incarnato, D., Gay, F., ... & Guccione, E. (2021). HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness. Elife, 10, e59654.

Ramesh, N., Kour, S., Anderson, E. N., Rajasundaram, D., & Pandey, U. B. (2020). RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM. Acta neuropathologica communications, 8, 1-22.

Cao, P., Luo, W. W., Li, C., Tong, Z., Zheng, Z. Q., Zhou, L., ... & Li, S. (2019). The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors. PLoS Pathogens, 15(8), e1007983.

West, K. O., Scott, H. M., Torres-Odio, S., West, A. P., Patrick, K. L., & Watson, R. O. (2019). The splicing factor hnRNP M is a critical regulator of innate immune gene expression in macrophages. Cell reports, 29(6), 1594-1609.

Chen, T. M., Lai, M. C., Li, Y. H., Chan, Y. L., Wu, C. H., Wang, Y. M., ... & Tsai, S. J. (2019). hnRNPM induces translation switch under hypoxia to promote colon cancer development. EBioMedicine, 41, 299-309.

Harvey, S. E., Xu, Y., Lin, X., Gao, X. D., Qiu, Y., Ahn, J., ... & Cheng, C. (2018). Coregulation of alternative splicing by hnRNPM and ESRP1 during EMT. Rna, 24(10), 1326-1338.

Zhang, F. L., Cao, J. L., Xie, H. Y., Sun, R., Yang, L. F., Shao, Z. M., & Li, D. Q. (2018). Cancer-associated MORC2-mutant M276I regulates an hnRNPM-mediated CD44 splicing switch to promote invasion and metastasis in triple-negative breast cancer. Cancer research, 78(20), 5780-5792.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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