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Mouse Anti-HNRNPM Recombinant Antibody (CBT2978) (V2LY-0625-LY1037)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBT2978
Antibody Isotype
IgG1
Application
WB, IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human NAGR1 (AA: 17-161) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
heterogeneous nuclear ribonucleoprotein M
Entrez Gene ID
4670
UniProt ID
P52272
Function
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
Biological Process
Alternative mRNA splicing, via spliceosome Source: BHF-UCL
mRNA splicing, via spliceosome Source: UniProtKB
Regulation of mRNA stability involved in response to oxidative stress Source: GO_Central
Cellular Location
Nucleolus
PTM
Sumoylated.
More Infomation

Zhu, G. Q., Wang, Y., Wang, B., Liu, W. R., Dong, S. S., Chen, E. B., ... & Dai, Z. (2022). Targeting HNRNPM inhibits cancer stemness and enhances antitumor immunity in Wnt-activated hepatocellular carcinoma. Cellular and Molecular Gastroenterology and Hepatology, 13(5), 1413-1447.

Kamo, M., Ito, M., Toma, T., Gotoh, H., Shimozono, R., Nakagawa, R., ... & Fujita, M. (2021). Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M. Bioorganic Chemistry, 107, 104627.

Wang, X., Li, J., Bian, X., Wu, C., Hua, J., Chang, S., ... & Lin, W. (2021). CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer. Proceedings of the National Academy of Sciences, 118(33), e2012881118.

Ho, J. S., Di Tullio, F., Schwarz, M., Low, D., Incarnato, D., Gay, F., ... & Guccione, E. (2021). HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness. Elife, 10, e59654.

Ramesh, N., Kour, S., Anderson, E. N., Rajasundaram, D., & Pandey, U. B. (2020). RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM. Acta neuropathologica communications, 8, 1-22.

Cao, P., Luo, W. W., Li, C., Tong, Z., Zheng, Z. Q., Zhou, L., ... & Li, S. (2019). The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors. PLoS Pathogens, 15(8), e1007983.

West, K. O., Scott, H. M., Torres-Odio, S., West, A. P., Patrick, K. L., & Watson, R. O. (2019). The splicing factor hnRNP M is a critical regulator of innate immune gene expression in macrophages. Cell reports, 29(6), 1594-1609.

Chen, T. M., Lai, M. C., Li, Y. H., Chan, Y. L., Wu, C. H., Wang, Y. M., ... & Tsai, S. J. (2019). hnRNPM induces translation switch under hypoxia to promote colon cancer development. EBioMedicine, 41, 299-309.

Harvey, S. E., Xu, Y., Lin, X., Gao, X. D., Qiu, Y., Ahn, J., ... & Cheng, C. (2018). Coregulation of alternative splicing by hnRNPM and ESRP1 during EMT. Rna, 24(10), 1326-1338.

Zhang, F. L., Cao, J. L., Xie, H. Y., Sun, R., Yang, L. F., Shao, Z. M., & Li, D. Q. (2018). Cancer-associated MORC2-mutant M276I regulates an hnRNPM-mediated CD44 splicing switch to promote invasion and metastasis in triple-negative breast cancer. Cancer research, 78(20), 5780-5792.

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For research use only. Not intended for any clinical use.

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