HNRNPM
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants.
Full Name
heterogeneous nuclear ribonucleoprotein M
Function
Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.
Biological Process
Alternative mRNA splicing, via spliceosome Source: BHF-UCL
mRNA splicing, via spliceosome Source: UniProtKB
Regulation of mRNA stability involved in response to oxidative stress Source: GO_Central
mRNA splicing, via spliceosome Source: UniProtKB
Regulation of mRNA stability involved in response to oxidative stress Source: GO_Central
Cellular Location
Nucleolus
PTM
Sumoylated.
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Anti-HNRNPM antibodies
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CompareTarget: HNRNPM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2267
Application*: WB, IH, IC, F
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBT2978
Application*: WB, IH, IC, F
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 3F7
Application*: WB, E
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B6
Application*: WB, E
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Human
Clone: CBFYH-1675
Application*: WB, P, IF, SE
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1674
Application*: WB, P
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-1673
Application*: WB
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1672
Application*: P
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-1671
Application*: WB, IH
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-1670
Application*: E, IF, P, WB
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1669
Application*: IP, WB
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1668
Application*: WB, IH
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rabbit, Rat
Clone: CBFYH-1667
Application*: IP, WB
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Human
Clone: CBFYH-1666
Application*: WB, IP
Target: HNRNPM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Cattle, Human, Mouse, Pig, Rat
Clone: CBFYH-2898
Application*: IP, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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