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Mouse Anti-HOXA7 Recombinant Antibody (2F2) (CBMAB-A4031-LY)

The product is antibody recognizes HOXA7. The antibody 2F2 immunoassay techniques such as: WB, ELISA.
See all HOXA7 antibodies
Published Data
Fig.1 Immunoblot analysis of HOX genes.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXA7 (NP_008827, 58 a.a. ~ 112 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
homeobox A7
Introduction
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq]
Entrez Gene ID
3204
UniProt ID
P31268
Alternative Names
ANTP; HOX1; HOX1.1; HOX1A
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Angiogenesis Source: UniProtKB
Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system morphogenesis Source: Ensembl
Negative regulation of cell-matrix adhesion Source: UniProtKB
Negative regulation of keratinocyte differentiation Source: MGI
Negative regulation of leukocyte migration Source: UniProtKB
Negative regulation of monocyte differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Stem cell differentiation Source: Ensembl
Cellular Location
Nucleus

Li, J., Han, J., Zhao, A., & Zhang, G. (2022). CircPAPPA regulates the proliferation, migration, invasion, apoptosis, and cell cycle of trophoblast cells through the miR-3127-5p/HOXA7 axis. Reproductive Sciences, 1-11.

Dang, Y., Yu, J., Zhao, S., Cao, X., & Wang, Q. (2022). HOXA7 promotes the metastasis of KRAS mutant colorectal cancer by regulating myeloid-derived suppressor cells. Cancer Cell International, 22(1), 88.

Chen, Q., Pan, Q., Gao, H., Wang, Y., & Zhong, X. (2022). miR-17-5p/HOXA7 is a potential driver for brain metastasis of lung adenocarcinoma related to ferroptosis revealed by bioinformatic analysis. Frontiers in neurology, 13, 878947.

Chen, H., Zhang, Y., Wu, K., & Qiu, X. (2021). circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis. Journal of International Medical Research, 49(6), 03000605211013207.

Wang, S., Diao, Y. J., & Zhu, B. B. (2020). MiR-193a-5p suppresses cell proliferation and induces cell apoptosis by regulating HOXA7 in human ovarian cancer. Neoplasma, 67(4), 825-833.

Ji, F., Du, R., Chen, T., Zhang, M., Zhu, Y., Luo, X., & Ding, Y. (2020). Circular RNA circSLC26A4 accelerates cervical cancer progression via miR-1287-5p/HOXA7 axis. Molecular Therapy-Nucleic Acids, 19, 413-420.

Zha, J. P., Wang, X. Q., & Di, J. (2020). MiR-920 promotes osteogenic differentiation of human bone mesenchymal stem cells by targeting HOXA7. Journal of Orthopaedic Surgery and Research, 15, 1-8.

Bao, J., Zhang, S., Meng, Q., & Qin, T. (2020). SNHG16 silencing inhibits neuroblastoma progression by downregulating HOXA7 via sponging miR-128-3p. Neurochemical Research, 45, 825-836.

Xu, Y., Wu, D., Liu, J., Huang, S., Zuo, Q., Xia, X., ... & Sun, L. (2018). Downregulated lncRNA HOXA11-AS affects trophoblast cell proliferation and migration by regulating RND3 and HOXA7 expression in PE. Molecular Therapy-Nucleic Acids, 12, 195-206.

Liu, S., Lei, H., Luo, F., Li, Y., & Xie, L. (2018). The effect of lncRNA HOTAIR on chemoresistance of ovarian cancer through regulation of HOXA7. Biological Chemistry, 399(5), 485-497.

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For research use only. Not intended for any clinical use.

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