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  • Rabbit Anti-HOXA7 Recombinant Antibody (EG1544)

Rabbit Anti-HOXA7 Recombinant Antibody (EG1544) (CBMAB-EN1843-LY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
EG1544
Application
WB: 1:500~1:1000 ELISA: 1:40000
Immunogen
The antibody was produced against synthesized peptide derived from internal of human HOXA7.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
homeobox A7
Introduction
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.
Entrez Gene ID
Human3204
Mouse15404
Rat500126
UniProt ID
HumanP31268
MouseP02830
RatP09634
Alternative Names
ANTP; HOX1; HOX1A; HOX1.1
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Angiogenesis Source: UniProtKB
Anterior/posterior pattern specification Source: GO_Central
Embryonic skeletal system morphogenesis Source: Ensembl
Negative regulation of cell-matrix adhesion Source: UniProtKB
Negative regulation of keratinocyte differentiation Source: MGI
Negative regulation of leukocyte migration Source: UniProtKB
Negative regulation of monocyte differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Stem cell differentiation Source: Ensembl
Cellular Location
Nucleus

Li, J., Han, J., Zhao, A., & Zhang, G. (2022). CircPAPPA regulates the proliferation, migration, invasion, apoptosis, and cell cycle of trophoblast cells through the miR-3127-5p/HOXA7 axis. Reproductive Sciences, 1-11.

Dang, Y., Yu, J., Zhao, S., Cao, X., & Wang, Q. (2022). HOXA7 promotes the metastasis of KRAS mutant colorectal cancer by regulating myeloid-derived suppressor cells. Cancer Cell International, 22(1), 88.

Chen, Q., Pan, Q., Gao, H., Wang, Y., & Zhong, X. (2022). miR-17-5p/HOXA7 is a potential driver for brain metastasis of lung adenocarcinoma related to ferroptosis revealed by bioinformatic analysis. Frontiers in neurology, 13, 878947.

Chen, H., Zhang, Y., Wu, K., & Qiu, X. (2021). circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis. Journal of International Medical Research, 49(6), 03000605211013207.

Wang, S., Diao, Y. J., & Zhu, B. B. (2020). MiR-193a-5p suppresses cell proliferation and induces cell apoptosis by regulating HOXA7 in human ovarian cancer. Neoplasma, 67(4), 825-833.

Ji, F., Du, R., Chen, T., Zhang, M., Zhu, Y., Luo, X., & Ding, Y. (2020). Circular RNA circSLC26A4 accelerates cervical cancer progression via miR-1287-5p/HOXA7 axis. Molecular Therapy-Nucleic Acids, 19, 413-420.

Zha, J. P., Wang, X. Q., & Di, J. (2020). MiR-920 promotes osteogenic differentiation of human bone mesenchymal stem cells by targeting HOXA7. Journal of Orthopaedic Surgery and Research, 15, 1-8.

Bao, J., Zhang, S., Meng, Q., & Qin, T. (2020). SNHG16 silencing inhibits neuroblastoma progression by downregulating HOXA7 via sponging miR-128-3p. Neurochemical Research, 45, 825-836.

Xu, Y., Wu, D., Liu, J., Huang, S., Zuo, Q., Xia, X., ... & Sun, L. (2018). Downregulated lncRNA HOXA11-AS affects trophoblast cell proliferation and migration by regulating RND3 and HOXA7 expression in PE. Molecular Therapy-Nucleic Acids, 12, 195-206.

Liu, S., Lei, H., Luo, F., Li, Y., & Xie, L. (2018). The effect of lncRNA HOTAIR on chemoresistance of ovarian cancer through regulation of HOXA7. Biological Chemistry, 399(5), 485-497.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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