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Mouse Anti-HOXC8 Recombinant Antibody (V2-614372) (CBMAB-A4065-LY)

The product is antibody recognizes HOXC8. The antibody 5G1 immunoassay techniques such as: WB, ELISA.
See all HOXC8 antibodies
Published Data
Fig. 1 MDA-MB-231 cells were lentivirally transduced with empty vector (control) or vector encoding miR-196a2, miR-196a2mut, miR-196a2rev, miR-196b, or miR-196bmut, then lysed and cell lysates subjected to immunoblotting to detect HOXC8 protein with HOXC8 mAb.
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Fig. 2 Immunohistochemistry of HOXC8 in breast tumor tissues.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-614372
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXC8 (NP_073149, 47 a.a. ~ 136 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Homeobox C8
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq]
Entrez Gene ID
3224
UniProt ID
P31273
Alternative Names
HOX3; HOX3A
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Neuron differentiation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal system morphogenesis Source: Ensembl
Cellular Location
Nucleus

Cui, W., Zhang, Q., Wang, H., Zhang, X., Tian, M., Liu, D., & Yang, X. (2023). Effects of HOXC8 on the Proliferation and Differentiation of Porcine Preadipocytes. Animals, 13(16), 2615.

Xu, D., Gao, C., Cao, Y., & Xiao, B. (2023). HOXC8 alleviates high glucose-triggered damage of trophoblast cells during gestational diabetes mellitus via activating TGFβ1-mediated Notch1 pathway. Human Cell, 36(1), 195-208.

Catela, C., Chen, Y., Weng, Y., Wen, K., & Kratsios, P. (2022). Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. Elife, 11, e70766.

Li, M., Cai, J., Han, X., & Ren, Y. (2020). Downregulation of circNRIP1 suppresses the paclitaxel resistance of ovarian cancer via regulating the miR-211-5p/HOXC8 axis. Cancer management and research, 9159-9171.

Mihara, Y., Maekawa, R., Sato, S., Shimizu, N., Doi-Tanaka, Y., Takagi, H., ... & Sugino, N. (2020). An integrated genomic approach identifies HOXC8 as an upstream regulator in ovarian endometrioma. The Journal of Clinical Endocrinology & Metabolism, 105(12), e4474-e4489.

Yang, H., Cao, Y., Zhang, J., Liang, Y., Su, X., Zhang, C., ... & Fan, Z. (2020). DLX5 and HOXC8 enhance the chondrogenic differentiation potential of stem cells from apical papilla via LINC01013. Stem cell research & therapy, 11, 1-16.

Zhang, Q., Ni, T., Dang, Y., Ding, L., Jiang, J., Li, J., ... & Chen, Z. J. (2020). MiR-148a-3p may contribute to flawed decidualization in recurrent implantation failure by modulating HOXC8. Journal of Assisted Reproduction and Genetics, 37, 2535-2544.

Gong, C., Zou, J., Zhang, M., Zhang, J., Xu, S., Zhu, S., ... & Li, Y. (2019). Upregulation of MGP by HOXC8 promotes the proliferation, migration, and EMT processes of triple‐negative breast cancer. Molecular carcinogenesis, 58(10), 1863-1875.

Huang, Y., Chen, L., & Guo, A. (2018). Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer. Oncology letters, 15(5), 7291-7296.

Liu, H., Zhang, M., Xu, S., Zhang, J., Zou, J., Yang, C., ... & Li, Y. (2018). HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFβ1 in non-small cell lung cancer. Oncogenesis, 7(2), 1.

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For research use only. Not intended for any clinical use.

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