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Mouse Anti-HOXD10 (AA 80-340) Recombinant Antibody (CBFYH-1834) (CBMAB-H2844-FY)

This product is mouse antibody that recognizes HOXD10. The antibody CBFYH-1834 can be used for immunoassay techniques such as: IHC-P.
See all HOXD10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1834
Antibody Isotype
IgG2b
Application
IHC-P

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 80-340 of human HOXD10 produced in E. coli.
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 80-340

Target

Full Name
homeobox D10
Introduction
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.
Entrez Gene ID
3236
UniProt ID
P28358
Alternative Names
Homeobox D10; Homeobox Protein Hox-4D; Homeobox Protein Hox-4E; Homeo Box D10; HOX4D; HOX4E
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Adult locomotory behavior Source: Ensembl
Anterior/posterior pattern specification Source: Ensembl
Embryonic limb morphogenesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Forelimb morphogenesis Source: Ensembl
Hindlimb morphogenesis Source: Ensembl
Neuromuscular process Source: Ensembl
Peripheral nervous system neuron development Source: Ensembl
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Single fertilization Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Spinal cord motor neuron cell fate specification Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Vertical talus, congenital (CVT):
A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence.

Li, Y., Ma, K., Xie, Q., Zhang, X., Zhang, X., Chen, K., ... & Qian, R. (2021). Identification of HOXD10 as a marker of poor prognosis in glioblastoma multiforme. OncoTargets and therapy, 5183-5195.

Lai, F. J., Yu, H., Xie, Y. Y., & He, N. (2021). Circ_0000317/microRNA‐520g/HOXD10 axis affects the biological characteristics of colorectal cancer. The Kaohsiung Journal of Medical Sciences, 37(11), 951-963.

Pan, W., Wang, K., Li, J., Li, H., Cai, Y., Zhang, M., ... & Weng, W. (2021). Restoring HOXD10 exhibits therapeutic potential for ameliorating malignant progression and 5-fluorouracil resistance in colorectal cancer. Frontiers in oncology, 11, 771528.

Ruan, Z., Li, Y., He, R., & Li, X. (2021). Inhibition of microRNA-10b-5p up-regulates HOXD10 to attenuate Alzheimer’s disease in rats via the Rho/ROCK signalling pathway. Journal of drug targeting, 29(5), 531-540.

Yang, F., Liu, D., Deng, Y., Wang, J., Mei, S., Ge, S., ... & Zhang, T. (2020). Frequent promoter methylation of HOXD10 in endometrial carcinoma and its pathological significance. Oncology Letters, 19(5), 3602-3608.

Lin, Z., Hu, Y., Lin, R., & Ye, H. (2020). The effect of overexpression of the HOXD10 gene on the malignant proliferation, invasion, and tumor formation of pancreatic cancer cell PANC-1. Gland Surgery, 9(2), 385.

Yuan, Y. H., Wang, H. Y., Lai, Y., Zhong, W., Liang, W. L., Yan, F. D., ... & Lin, Y. (2019). Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway. Cell Communication and Signaling, 17, 1-13.

Qi, Z., Yuan, L., & Sun, N. (2019). Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway. Oncology Letters, 18(6), 6228-6236.

Cao, Y. M., Gu, J., Zhang, Y. S., Wei, W. J., Qu, N., Wen, D., ... & Zhu, Y. X. (2018). Aberrant hypermethylation of the HOXD10 gene in papillary thyroid cancer with BRAFV600E mutation. Oncology reports, 39(1), 338-348.

Yachi, K., Tsuda, M., Kohsaka, S., Wang, L., Oda, Y., Tanikawa, S., ... & Tanaka, S. (2018). miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition. Signal Transduction and Targeted Therapy, 3(1), 33.

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For research use only. Not intended for any clinical use.

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