Rabbit Anti-HOXD10 Recombinant Antibody (EG1548) (CBMAB-EN1847-LY)

Name: Rabbit Anti-HOXD10 Recombinant Antibody (EG1548)
SKU: CBMAB-EN1847-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1548

Application

WB: 1:500~1:1000 ELISA: 1:40000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human HOXD10.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

homeobox D10

Introduction

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.

Entrez Gene ID

Human	3236
Mouse	15430

UniProt ID

Human	P28358
Mouse	P28359

Alternative Names

HOX4; HOX4D; HOX4E; Hox-4.4

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Adult locomotory behavior Source: Ensembl
Anterior/posterior pattern specification Source: Ensembl
Embryonic limb morphogenesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Forelimb morphogenesis Source: Ensembl
Hindlimb morphogenesis Source: Ensembl
Neuromuscular process Source: Ensembl
Peripheral nervous system neuron development Source: Ensembl
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Single fertilization Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Spinal cord motor neuron cell fate specification Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

Vertical talus, congenital (CVT):
A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence.

Li, Y., Ma, K., Xie, Q., Zhang, X., Zhang, X., Chen, K., ... & Qian, R. (2021). Identification of HOXD10 as a marker of poor prognosis in glioblastoma multiforme. OncoTargets and therapy, 5183-5195.

Lai, F. J., Yu, H., Xie, Y. Y., & He, N. (2021). Circ_0000317/microRNA‐520g/HOXD10 axis affects the biological characteristics of colorectal cancer. The Kaohsiung Journal of Medical Sciences, 37(11), 951-963.

Pan, W., Wang, K., Li, J., Li, H., Cai, Y., Zhang, M., ... & Weng, W. (2021). Restoring HOXD10 exhibits therapeutic potential for ameliorating malignant progression and 5-fluorouracil resistance in colorectal cancer. Frontiers in oncology, 11, 771528.

Ruan, Z., Li, Y., He, R., & Li, X. (2021). Inhibition of microRNA-10b-5p up-regulates HOXD10 to attenuate Alzheimer’s disease in rats via the Rho/ROCK signalling pathway. Journal of drug targeting, 29(5), 531-540.

Yang, F., Liu, D., Deng, Y., Wang, J., Mei, S., Ge, S., ... & Zhang, T. (2020). Frequent promoter methylation of HOXD10 in endometrial carcinoma and its pathological significance. Oncology Letters, 19(5), 3602-3608.

Lin, Z., Hu, Y., Lin, R., & Ye, H. (2020). The effect of overexpression of the HOXD10 gene on the malignant proliferation, invasion, and tumor formation of pancreatic cancer cell PANC-1. Gland Surgery, 9(2), 385.

Yuan, Y. H., Wang, H. Y., Lai, Y., Zhong, W., Liang, W. L., Yan, F. D., ... & Lin, Y. (2019). Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway. Cell Communication and Signaling, 17, 1-13.

Qi, Z., Yuan, L., & Sun, N. (2019). Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway. Oncology Letters, 18(6), 6228-6236.

Cao, Y. M., Gu, J., Zhang, Y. S., Wei, W. J., Qu, N., Wen, D., ... & Zhu, Y. X. (2018). Aberrant hypermethylation of the HOXD10 gene in papillary thyroid cancer with BRAFV600E mutation. Oncology reports, 39(1), 338-348.

Yachi, K., Tsuda, M., Kohsaka, S., Wang, L., Oda, Y., Tanikawa, S., ... & Tanaka, S. (2018). miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition. Signal Transduction and Targeted Therapy, 3(1), 33.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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