Mouse Hoxd10 ELISA Kit (V2LY-0626-LY5873)

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Tested Data
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Basic Information

Sensitivity
0.0097 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
38.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
homeobox D10
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Adult locomotory behavior Source: Ensembl
Anterior/posterior pattern specification Source: Ensembl
Embryonic limb morphogenesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Forelimb morphogenesis Source: Ensembl
Hindlimb morphogenesis Source: Ensembl
Neuromuscular process Source: Ensembl
Peripheral nervous system neuron development Source: Ensembl
Proximal/distal pattern formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Single fertilization Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Spinal cord motor neuron cell fate specification Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Vertical talus, congenital (CVT):
A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence.

Li, Y., Ma, K., Xie, Q., Zhang, X., Zhang, X., Chen, K., ... & Qian, R. (2021). Identification of HOXD10 as a marker of poor prognosis in glioblastoma multiforme. OncoTargets and therapy, 5183-5195.

Lai, F. J., Yu, H., Xie, Y. Y., & He, N. (2021). Circ_0000317/microRNA‐520g/HOXD10 axis affects the biological characteristics of colorectal cancer. The Kaohsiung Journal of Medical Sciences, 37(11), 951-963.

Pan, W., Wang, K., Li, J., Li, H., Cai, Y., Zhang, M., ... & Weng, W. (2021). Restoring HOXD10 exhibits therapeutic potential for ameliorating malignant progression and 5-fluorouracil resistance in colorectal cancer. Frontiers in oncology, 11, 771528.

Ruan, Z., Li, Y., He, R., & Li, X. (2021). Inhibition of microRNA-10b-5p up-regulates HOXD10 to attenuate Alzheimer’s disease in rats via the Rho/ROCK signalling pathway. Journal of drug targeting, 29(5), 531-540.

Yang, F., Liu, D., Deng, Y., Wang, J., Mei, S., Ge, S., ... & Zhang, T. (2020). Frequent promoter methylation of HOXD10 in endometrial carcinoma and its pathological significance. Oncology Letters, 19(5), 3602-3608.

Lin, Z., Hu, Y., Lin, R., & Ye, H. (2020). The effect of overexpression of the HOXD10 gene on the malignant proliferation, invasion, and tumor formation of pancreatic cancer cell PANC-1. Gland Surgery, 9(2), 385.

Yuan, Y. H., Wang, H. Y., Lai, Y., Zhong, W., Liang, W. L., Yan, F. D., ... & Lin, Y. (2019). Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway. Cell Communication and Signaling, 17, 1-13.

Qi, Z., Yuan, L., & Sun, N. (2019). Propofol exhibits a tumor‑suppressive effect and regulates cell viability, migration and invasion in bladder carcinoma by targeting the microRNA‑10b/HOXD10 signaling pathway. Oncology Letters, 18(6), 6228-6236.

Cao, Y. M., Gu, J., Zhang, Y. S., Wei, W. J., Qu, N., Wen, D., ... & Zhu, Y. X. (2018). Aberrant hypermethylation of the HOXD10 gene in papillary thyroid cancer with BRAFV600E mutation. Oncology reports, 39(1), 338-348.

Yachi, K., Tsuda, M., Kohsaka, S., Wang, L., Oda, Y., Tanikawa, S., ... & Tanaka, S. (2018). miR-23a promotes invasion of glioblastoma via HOXD10-regulated glial-mesenchymal transition. Signal Transduction and Targeted Therapy, 3(1), 33.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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