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Mouse Anti-HSD17B1 Recombinant Antibody (2E5) (CBMAB-A4099-LY)

The product is antibody recognizes HSD17B1. The antibody 2E5 immunoassay techniques such as: WB, ELISA.
See all HSD17B1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HSD17B1 (NP_000404, 189 a.a. ~ 285 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
hydroxysteroid (17-beta) dehydrogenase 1
Entrez Gene ID
3292
UniProt ID
P14061
Alternative Names
EDH17B2; EDHB17; HSD17; MGC138140; SDR28C1
Function
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190).

Also has 20-alpha-HSD activity. Uses preferentially NADH.
Biological Process
Bone development Source: Ensembl
Cellular response to metal ion Source: Ensembl
Estrogen biosynthetic process Source: UniProtKB
Estrogen metabolic process Source: ProtInc
Steroid biosynthetic process Source: ProtInc
Testosterone biosynthetic process Source: UniProtKB
Cellular Location
Cytoplasm

Ruan, G. Y., Ye, L. X., Lin, J. S., Lin, H. Y., Yu, L. R., Wang, C. Y., ... & Sun, P. M. (2023). An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer. Journal of Translational Medicine, 21(1), 1-19.

Yazawa, T., Islam, M. S., Imamichi, Y., Watanabe, H., Yaegashi, K., Ida, T., ... & Muranishi, Y. (2023). Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian Species. Animals, 13(4), 622.

Kumar, G. G., Paul, S. F., Molia, C., Manickavasagam, M., Ramya, R., Rani, G. U., ... & Mary, F. A. (2022). The association between CYP17A1, CYP19A1, and HSD17B1 gene polymorphisms of estrogen synthesis pathway and ovarian cancer predisposition. Meta Gene, 31, 100985.

Singha, S., Pandey, M., Jaiswal, L., Dash, S., Fernandes, A., Kumaresan, A., ... & Baithalu, R. K. (2022). Salivary cell-free HSD17B1 and HSPA1A transcripts as potential biomarkers for estrus identification in buffaloes (Bubalus bubalis). Animal Biotechnology, 1-11.

Fan, B., Xie, D., Li, Y., Wang, X., Qi, X., Li, S., ... & Wang, L. (2021). A single intronic single nucleotide polymorphism in splicing site of steroidogenic enzyme hsd17b1 is associated with phenotypic sex in oyster pompano, Trachinotus anak. Proceedings of the Royal Society B, 288(1963), 20212245.

Yuan, X., Zhou, X., Qiao, X., Wu, Q., Yao, Z., Jiang, Y., ... & Li, J. (2021). FoxA2 and p53 regulate the transcription of HSD17B1 in ovarian granulosa cells of pigs. Reproduction in Domestic Animals, 56(1), 74-82.

Cheng, C., Shen, F., Ding, G., Liu, A., Chu, S., Ma, Y., ... & Bai, G. (2020). Lepidiline A improves the balance of endogenous sex hormones and increases fecundity by targeting HSD17B1. Molecular nutrition & food research, 64(10), 1900706.

Järvensivu, P., Heinosalo, T., Hakkarainen, J., Kronqvist, P., Saarinen, N., & Poutanen, M. (2018). HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium. Endocrine-Related Cancer, 25(4), 393-406.

Osiński, M., Wirstlein, P., Wender-Ożegowska, E., Mikołajczyk, M., Jagodziński, P. P., & Szczepańska, M. (2018). HSD3B2, HSD17B1, HSD17B2, ESR1, ESR2 and AR expression in infertile women with endometriosis. Ginekologia polska, 89(3), 125-134.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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