Rat Hsd17b1 ELISA Kit (V2LY-0626-LY1550)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.107 ng/mL
Detection Range
0.2-60 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
37.0 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
hydroxysteroid (17-beta) dehydrogenase 1
Function
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190).

Also has 20-alpha-HSD activity. Uses preferentially NADH.
Biological Process
Bone development Source: Ensembl
Cellular response to metal ion Source: Ensembl
Estrogen biosynthetic process Source: UniProtKB
Estrogen metabolic process Source: ProtInc
Steroid biosynthetic process Source: ProtInc
Testosterone biosynthetic process Source: UniProtKB
Cellular Location
Cytoplasm

Ruan, G. Y., Ye, L. X., Lin, J. S., Lin, H. Y., Yu, L. R., Wang, C. Y., ... & Sun, P. M. (2023). An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer. Journal of Translational Medicine, 21(1), 1-19.

Yazawa, T., Islam, M. S., Imamichi, Y., Watanabe, H., Yaegashi, K., Ida, T., ... & Muranishi, Y. (2023). Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian Species. Animals, 13(4), 622.

Kumar, G. G., Paul, S. F., Molia, C., Manickavasagam, M., Ramya, R., Rani, G. U., ... & Mary, F. A. (2022). The association between CYP17A1, CYP19A1, and HSD17B1 gene polymorphisms of estrogen synthesis pathway and ovarian cancer predisposition. Meta Gene, 31, 100985.

Singha, S., Pandey, M., Jaiswal, L., Dash, S., Fernandes, A., Kumaresan, A., ... & Baithalu, R. K. (2022). Salivary cell-free HSD17B1 and HSPA1A transcripts as potential biomarkers for estrus identification in buffaloes (Bubalus bubalis). Animal Biotechnology, 1-11.

Fan, B., Xie, D., Li, Y., Wang, X., Qi, X., Li, S., ... & Wang, L. (2021). A single intronic single nucleotide polymorphism in splicing site of steroidogenic enzyme hsd17b1 is associated with phenotypic sex in oyster pompano, Trachinotus anak. Proceedings of the Royal Society B, 288(1963), 20212245.

Yuan, X., Zhou, X., Qiao, X., Wu, Q., Yao, Z., Jiang, Y., ... & Li, J. (2021). FoxA2 and p53 regulate the transcription of HSD17B1 in ovarian granulosa cells of pigs. Reproduction in Domestic Animals, 56(1), 74-82.

Cheng, C., Shen, F., Ding, G., Liu, A., Chu, S., Ma, Y., ... & Bai, G. (2020). Lepidiline A improves the balance of endogenous sex hormones and increases fecundity by targeting HSD17B1. Molecular nutrition & food research, 64(10), 1900706.

Järvensivu, P., Heinosalo, T., Hakkarainen, J., Kronqvist, P., Saarinen, N., & Poutanen, M. (2018). HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium. Endocrine-Related Cancer, 25(4), 393-406.

Osiński, M., Wirstlein, P., Wender-Ożegowska, E., Mikołajczyk, M., Jagodziński, P. P., & Szczepańska, M. (2018). HSD3B2, HSD17B1, HSD17B2, ESR1, ESR2 and AR expression in infertile women with endometriosis. Ginekologia polska, 89(3), 125-134.

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For research use only. Not intended for any clinical use.

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