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Mouse Anti-HSD17B1 (AA 189-285) Recombinant Antibody (CBFYH-1995) (CBMAB-H3006-FY)

This product is mouse antibody that recognizes HSD17B1. The antibody CBFYH-1995 can be used for immunoassay techniques such as: ELISA, WB.
See all HSD17B1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1995
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: VHTAFMEKVL GSPEEVLDRT DIHTFHRFYQ YLAHSKQVFR EAAQNPEEVA EVFLTALRAP KPTLRYFTTE RFLPLLRMRL DDPSGSNYVT AMHREVF
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 189-285

Target

Full Name
hydroxysteroid (17-beta) dehydrogenase 1
Introduction
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
3292
UniProt ID
P14061
Alternative Names
Hydroxysteroid 17-Beta Dehydrogenase 1; Short Chain Dehydrogenase/Reductase Family 28CE, Member 1; Short Chain Dehydrogenase/Reductase Family 28C Member 1; Placental 17-Beta-Hydroxysteroid Dehydrogenase; 17-Beta-Hydroxysteroid Dehydrogenase Type 1; 20 Alpha-Hydroxysteroid Dehydrogenase; 17-Beta-HSD 1; 20-ALPHA-HSD; EDH17B2; SDR28C1; EDHB17
Function
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190).

Also has 20-alpha-HSD activity. Uses preferentially NADH.
Biological Process
Bone development Source: Ensembl
Cellular response to metal ion Source: Ensembl
Estrogen biosynthetic process Source: UniProtKB
Estrogen metabolic process Source: ProtInc
Steroid biosynthetic process Source: ProtInc
Testosterone biosynthetic process Source: UniProtKB
Cellular Location
Cytoplasm

Ruan, G. Y., Ye, L. X., Lin, J. S., Lin, H. Y., Yu, L. R., Wang, C. Y., ... & Sun, P. M. (2023). An integrated approach of network pharmacology, molecular docking, and experimental verification uncovers kaempferol as the effective modulator of HSD17B1 for treatment of endometrial cancer. Journal of Translational Medicine, 21(1), 1-19.

Yazawa, T., Islam, M. S., Imamichi, Y., Watanabe, H., Yaegashi, K., Ida, T., ... & Muranishi, Y. (2023). Comparison of Placental HSD17B1 Expression and Its Regulation in Various Mammalian Species. Animals, 13(4), 622.

Kumar, G. G., Paul, S. F., Molia, C., Manickavasagam, M., Ramya, R., Rani, G. U., ... & Mary, F. A. (2022). The association between CYP17A1, CYP19A1, and HSD17B1 gene polymorphisms of estrogen synthesis pathway and ovarian cancer predisposition. Meta Gene, 31, 100985.

Singha, S., Pandey, M., Jaiswal, L., Dash, S., Fernandes, A., Kumaresan, A., ... & Baithalu, R. K. (2022). Salivary cell-free HSD17B1 and HSPA1A transcripts as potential biomarkers for estrus identification in buffaloes (Bubalus bubalis). Animal Biotechnology, 1-11.

Fan, B., Xie, D., Li, Y., Wang, X., Qi, X., Li, S., ... & Wang, L. (2021). A single intronic single nucleotide polymorphism in splicing site of steroidogenic enzyme hsd17b1 is associated with phenotypic sex in oyster pompano, Trachinotus anak. Proceedings of the Royal Society B, 288(1963), 20212245.

Yuan, X., Zhou, X., Qiao, X., Wu, Q., Yao, Z., Jiang, Y., ... & Li, J. (2021). FoxA2 and p53 regulate the transcription of HSD17B1 in ovarian granulosa cells of pigs. Reproduction in Domestic Animals, 56(1), 74-82.

Cheng, C., Shen, F., Ding, G., Liu, A., Chu, S., Ma, Y., ... & Bai, G. (2020). Lepidiline A improves the balance of endogenous sex hormones and increases fecundity by targeting HSD17B1. Molecular nutrition & food research, 64(10), 1900706.

Järvensivu, P., Heinosalo, T., Hakkarainen, J., Kronqvist, P., Saarinen, N., & Poutanen, M. (2018). HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium. Endocrine-Related Cancer, 25(4), 393-406.

Osiński, M., Wirstlein, P., Wender-Ożegowska, E., Mikołajczyk, M., Jagodziński, P. P., & Szczepańska, M. (2018). HSD3B2, HSD17B1, HSD17B2, ESR1, ESR2 and AR expression in infertile women with endometriosis. Ginekologia polska, 89(3), 125-134.

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For research use only. Not intended for any clinical use.

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