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Mouse Anti-HSF2BP Recombinant Antibody (CBFYH-2061) (CBMAB-H3074-FY)

This product is mouse antibody that recognizes HSF2BP. The antibody CBFYH-2061 can be used for immunoassay techniques such as: ELISA, WB.
See all HSF2BP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2061
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
heat shock transcription factor 2 binding protein
Introduction
HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation.
Entrez Gene ID
11077
UniProt ID
O75031
Alternative Names
Heat Shock Transcription Factor 2 Binding Protein; Heat Shock Factor 2 Binding Protein
Function
Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed:31242413).

Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity).

Required for proper recombinase recruitment in female meiosis (By similarity).

Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).

May be involved in modulating HSF2 activation in testis (PubMed:9651507).
Biological Process
Double-strand break repair involved in meiotic recombination Source: UniProtKB
Female meiosis I Source: UniProtKB
Male meiosis I Source: UniProtKB
Spermatogenesis Source: UniProtKB
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Cytoplasm; Chromosome. Localizes on double-strand breaks (DSBs) in mitotic and meiotic chromosomes.
Involvement in disease
Premature ovarian failure 19 (POF19):
A form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. POF19 is an autosomal recessive form characterized by irregular menstrual cycles and cessation of menstruation in the third decade of life.
PTM
Sumoylated by UBE2I in response to MEKK1-mediated stimuli.

Ghouil, R., Miron, S., Sato, K., Ristic, D., van Rossum-Fikkert, S. E., Legrand, P., ... & Zinn-Justin, S. (2023). BRCA2-HSF2BP Oligomeric Ring Disassembly by BRME1 Promotes Homologous Recombination. bioRxiv, 2023-04.

Bi, J., Zhang, J., Ke, M., Wang, T., Wang, M., Liu, W., ... & Wu, R. (2022). HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice. Cell Death & Disease, 13(9), 830.

Li, S., Xu, W., Xu, B., Gao, S., Zhang, Q., Qin, Y., & Guo, T. (2022). Pathogenic variations of homologous recombination gene HSF2BP identified in sporadic patients with premature ovarian insufficiency. Frontiers in Cell and Developmental Biology, 9, 768123.

Ghouil, R., Miron, S., Koornneef, L., Veerman, J., Paul, M. W., Le Du, M. H., ... & Zelensky, A. N. (2021). BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination. Nature Communications, 12(1), 4605.

Huang, Z., Liu, Z., Cheng, X., Han, Z., Li, J., Xia, T., ... & Wei, L. (2021). Prognostic significance of HSF2BP in lung adenocarcinoma. Annals of Translational Medicine, 9(20).

Felipe-Medina, N., Caburet, S., Sánchez-Sáez, F., Condezo, Y. B., De Rooij, D. G., Gómez-h, L., ... & Pendás, A. M. (2020). A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1. Elife, 9, e56996.

Sato, K., Brandsma, I., van Rossum-Fikkert, S. E., Verkaik, N., Oostra, A. B., Dorsman, J. C., ... & Zelensky, A. N. (2020). HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair. Nucleic Acids Research, 48(5), 2442-2456.

Ghouil, R., Miron, S., Koornneef, L., Veerman, J., Paul, M. W., Le Du, M. H., ... & Zelensky, A. N. (2020). A cryptic BRCA2 repeated motif binds to HSF2BP oligomers with no impact on meiotic recombination. bioRxiv, 2020-12.

Brandsma, I., Sato, K., van Rossum-Fikkert, S. E., van Vliet, N., Sleddens, E., Reuter, M., ... & Zelensky, A. N. (2019). HSF2BP interacts with a conserved domain of BRCA2 and is required for mouse spermatogenesis. Cell reports, 27(13), 3790-3798.

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For research use only. Not intended for any clinical use.

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