HSF2BP

HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq]

Full Name

heat shock transcription factor 2 binding protein

Function

Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed:31242413).

Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity).

Required for proper recombinase recruitment in female meiosis (By similarity).

Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).

May be involved in modulating HSF2 activation in testis (PubMed:9651507).

Biological Process

Double-strand break repair involved in meiotic recombination Source: UniProtKB
Female meiosis I Source: UniProtKB
Male meiosis I Source: UniProtKB
Spermatogenesis Source: UniProtKB
Transcription by RNA polymerase II Source: ProtInc

Cellular Location

Cytoplasm; Chromosome. Localizes on double-strand breaks (DSBs) in mitotic and meiotic chromosomes.

Involvement in disease

Premature ovarian failure 19 (POF19):
A form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. POF19 is an autosomal recessive form characterized by irregular menstrual cycles and cessation of menstruation in the third decade of life.

PTM

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.