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Mouse Anti-HSH2D (AA 251-352) Recombinant Antibody (CBFYH-2076) (CBMAB-H3086-FY)

This product is mouse antibody that recognizes HSH2D. The antibody CBFYH-2076 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all HSH2D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2076
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: SQDHSGDPTS GDRGYTDPCV ATSLKSPSQP QAPKDRKVPT RKAERSVSCI EVTPGDRSWH QMVVRALSSQ ESKPEHQGLA EPENDQLPEE YQQPPPFAPG YC
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 251-352

Target

Full Name
HSH2D
Introduction
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).
Entrez Gene ID
84941
UniProt ID
Q96JZ2
Alternative Names
Hematopoietic SH2 Domain Containing; Adaptor In Lymphocytes Of Unknown Function X; ALX; Hematopoietic SH2 Domain-Containing Protein; Hematopoietic SH2 Protein; HSH2
Function
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity).

Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.
Biological Process
Negative regulation of B cell apoptotic process Source: Ensembl
Negative regulation of mitochondrial depolarization Source: Ensembl
Signal transduction Source: InterPro
T cell activation Source: Ensembl
Cellular Location
Cytoplasm; Nucleus
PTM
May be phosphorylated by FES and ACK1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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