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HSH2D

T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM

Full Name

HSH2D

Function

May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity).

Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.

Biological Process

Negative regulation of B cell apoptotic process Source: Ensembl
Negative regulation of mitochondrial depolarization Source: Ensembl
Signal transduction Source: InterPro
T cell activation Source: Ensembl

Cellular Location

Cytoplasm; Nucleus

PTM

May be phosphorylated by FES and ACK1.

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Anti-HSH2D antibodies

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Mouse Anti-HSH2D (AA 251-352) Recombinant Antibody (CBFYH-2076) (CBMAB-H3086-FY)

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Target: HSH2D

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-2076

Application*: E, P, WB

Mouse Anti-HSH2D Recombinant Antibody (6G7) (CBMAB-0618-CN)

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Target: HSH2D

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 6G7

Application*: E, M

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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