HSH2D

T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM

Full Name

HSH2D

Function

May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity).

Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.

Biological Process

Negative regulation of B cell apoptotic process Source: Ensembl
Negative regulation of mitochondrial depolarization Source: Ensembl
Signal transduction Source: InterPro
T cell activation Source: Ensembl

Cellular Location

Cytoplasm; Nucleus

PTM

May be phosphorylated by FES and ACK1.

Anti-HSH2D antibodies

Mouse Anti-HSH2D (AA 251-352) Recombinant Antibody (CBFYH-2076) (CBMAB-H3086-FY)

Datasheet

SDS

Target: HSH2D

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-2076

Application*: E, P, WB

Mouse Anti-HSH2D Recombinant Antibody (6G7) (CBMAB-0618-CN)

Datasheet

SDS

Target: HSH2D

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 6G7

Application*: E, M

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)