Mouse Anti-HSPA4 Recombinant Antibody (3A11) (CBMAB-A4127-LY)

Name: Mouse Anti-HSPA4 Recombinant Antibody (3A11)
SKU: CBMAB-A4127-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3A11

Application

WB, ELISA

Immunogen

HSPA4 (AAH02526, 1 a.a. ~ 148 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Heat Shock Protein Family A (Hsp70) Member 4

Entrez Gene ID

3308

UniProt ID

P34932

Alternative Names

APG-2; HS24/P52; MGC131852; RY; hsp70; hsp70RY

Biological Process

Chaperone-mediated protein complex assembly Source: BHF-UCL
Protein insertion into mitochondrial outer membrane Source: BHF-UCL
Response to unfolded protein Source: UniProtKB

Cellular Location

Cytoplasm

Yuan, X., Sun, X., Zhou, B., Zhao, S., Li, Y., & Ming, H. (2023). HSPA4 regulated glioma progression via activation of AKT signaling pathway. Biochemistry and Cell Biology, (ja).

Yang, Y., Zhang, S., Guan, J., Jiang, Y., Zhang, J., Luo, L., & Sun, C. (2022). SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson's disease. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1868(5), 166365.

Li, S. C., Lan, K. C., Hung, H. N., Huang, W. T., Lai, Y. J., Cheng, H. H., ... & Hsu, T. Y. (2022). HSPA4 is a biomarker of placenta accreta and enhances the angiogenesis ability of vessel endothelial cells. International Journal of Molecular Sciences, 23(10), 5682.

Sun, Q., Lv, Y., & Sun, W. (2022). Inhibition of DNAJC12 Inhibited Tumorigenesis of Rectal Cancer via Downregulating HSPA4 Expression. Evidence-based Complementary and Alternative Medicine: eCAM, 2022.

Shang, B. B., Chen, J., Wang, Z. G., & Liu, H. (2021). Significant correlation between HSPA4 and prognosis and immune regulation in hepatocellular carcinoma. PeerJ, 9, e12315.

Zhang, M., Dai, W., Li, Z., Tang, L., Chen, J., & Chen, C. (2021). HSPA4 knockdown retarded progression and development of colorectal cancer. Cancer Management and Research, 4679-4690.

Gu, Y., Liu, Y., Fu, L., Zhai, L., Zhu, J., Han, Y., ... & Cao, X. (2019). Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG. Nature medicine, 25(2), 312-322.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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