Mouse Anti-HSPA4 Recombinant Antibody (CBFYH-2259) (CBMAB-H0434-FY)

This product is mouse antibody that recognizes HSPA4. The antibody CBFYH-2259 can be used for immunoassay techniques such as: WB, IHC, IF.
See all HSPA4 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat, Amphibian, Chicken, Fruit fly, Fish, Yeast

Clone

CBFYH-2259

Antibody Isotype

IgM

Application

WB, IHC, IF

Basic Information

Immunogen

Human recombinant HSP70 overexpressed in E.coli

Specificity

Human, Mouse, Rat, Amphibian, Chicken, Fruit fly, Fish, Yeast

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Heat Shock Protein Family A (Hsp70) Member 4

Introduction

HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) is a Protein Coding gene. Diseases associated with HSPA4 include Ischemia and Leishmaniasis. Among its related pathways are Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics and CCR5 Pathway in Macrophages. An important paralog of this gene is HSPA4L.

Entrez Gene ID

Human	3308
Mouse	15525
Rat	266759
Chicken	416339
Zebrafish	334086

UniProt ID

Human	P34932
Mouse	Q61316
Rat	O88600
Chicken	A0A1D5PPF8
Zebrafish	Q6NZU0

Alternative Names

Heat Shock Protein Family A (Hsp70) Member 4; Heat Shock 70-Related Protein APG-2; Heat Shock 70kDa Protein 4; Heat Shock 70kD Protein 4; Hsp70 RY; Hsp70RY; Epididymis Secretory Sperm Binding Protein Li 5a; Heat Shock 70 KDa Protein 4; Heat Shock Protein, 110 KDa

Biological Process

Chaperone-mediated protein complex assembly Source: BHF-UCL
Protein insertion into mitochondrial outer membrane Source: BHF-UCL
Response to unfolded protein Source: UniProtKB

Cellular Location

Cytoplasm

References

Yuan, X., Sun, X., Zhou, B., Zhao, S., Li, Y., & Ming, H. (2023). HSPA4 regulated glioma progression via activation of AKT signaling pathway. Biochemistry and Cell Biology, (ja).

Yang, Y., Zhang, S., Guan, J., Jiang, Y., Zhang, J., Luo, L., & Sun, C. (2022). SIRT1 attenuates neuroinflammation by deacetylating HSPA4 in a mouse model of Parkinson's disease. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1868(5), 166365.

Li, S. C., Lan, K. C., Hung, H. N., Huang, W. T., Lai, Y. J., Cheng, H. H., ... & Hsu, T. Y. (2022). HSPA4 is a biomarker of placenta accreta and enhances the angiogenesis ability of vessel endothelial cells. International Journal of Molecular Sciences, 23(10), 5682.

Sun, Q., Lv, Y., & Sun, W. (2022). Inhibition of DNAJC12 Inhibited Tumorigenesis of Rectal Cancer via Downregulating HSPA4 Expression. Evidence-based Complementary and Alternative Medicine: eCAM, 2022.

Shang, B. B., Chen, J., Wang, Z. G., & Liu, H. (2021). Significant correlation between HSPA4 and prognosis and immune regulation in hepatocellular carcinoma. PeerJ, 9, e12315.

Zhang, M., Dai, W., Li, Z., Tang, L., Chen, J., & Chen, C. (2021). HSPA4 knockdown retarded progression and development of colorectal cancer. Cancer Management and Research, 4679-4690.

Gu, Y., Liu, Y., Fu, L., Zhai, L., Zhu, J., Han, Y., ... & Cao, X. (2019). Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG. Nature medicine, 25(2), 312-322.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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