Sign in or Register   Sign in or Register
  |  

Mouse Anti-HYAL3 (AA 1-417) Recombinant Antibody (CBFYH-2564) (CBMAB-H3586-FY)

This product is mouse antibody that recognizes HYAL3. The antibody CBFYH-2564 can be used for immunoassay techniques such as: ELISA.
See all HYAL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2564
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-417

Target

Full Name
hyaluronoglucosaminidase 3
Introduction
This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.
Entrez Gene ID
UniProt ID
Alternative Names
Hyaluronoglucosaminidase 3; Lung Carcinoma Protein 3; EC 3.2.1.35; HYAL-3; LUCA-3; LUCA3; Hyaluronoglucosaminidase-3; Hyaluronidase-3
Function
Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro.
Biological Process
Carbohydrate metabolic process Source: InterPro
Cartilage development Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Cellular response to UV-B Source: UniProtKB
Hyaluronan catabolic process Source: UniProtKB
Inflammatory response Source: UniProtKB
Negative regulation of ovarian follicle development Source: UniProtKB
Ovarian follicle atresia Source: UniProtKB
Penetration of zona pellucida Source: UniProtKB
Positive regulation of acrosomal vesicle exocytosis Source: UniProtKB
Response to antibiotic Source: UniProtKB
Response to virus Source: UniProtKB
Cellular Location
Secreted; Endoplasmic reticulum; Early endosome; Cell membrane; Acrosome. Mostly present in low-density vesicles. Low levels in higher density vesicles of late endosomes and lysosomes. Localized in punctate cytoplasmic vesicles and in perinuclear structures, but does not colocalize with LAMP1. Localized on the plasma membrane over the acrosome and on the surface of the midpiece of the sperm tail.
PTM
N-glycosylated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-HYAL3 (AA 1-417) Recombinant Antibody (CBFYH-2564)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare