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Rat Anti-ICAM2 Recombinant Antibody (3C4) (CBMAB-C1090-LY)

This product is antibody recognizes ICAM2. The antibody 3C4 immunoassay techniques such as: IHC-F, FuncS, IHC-P, FC.
See all ICAM2 antibodies
Published Data
Fig. 1 Unstimulated cremaster muscles were immunostained and observed for the expressions of ICAM-2.
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Fig. 2 The wild-type endothelioma line bEnd.5 was stained with ICAM-2 mAb 3C4.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
3C4
Antibody Isotype
IgG2a
Application
IHC-F, FuncS, IHC-P, FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Intercellular Adhesion Molecule 2
Introduction
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
15896
UniProt ID
P35330
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Cellular Location
Membrane; Microvillus. Co-localizes with RDX, EZR and MSN in microvilli.
Topology
Extracellular: 25-223
Helical: 224-248
Cytoplasmic: 249-275

Pan, J. K., Lin, W. D., Kuo, Y. L., Chen, Y. C., Loh, Z. J., Lin, F. C., ... & Lu, P. J. (2023). ICAM2 initiates trans-blood-CSF barrier migration and stemness properties in leptomeningeal metastasis of triple-negative breast cancer. Oncogene, 1-13.

Grönloh, M. L., Tebbens, M. E., Kotsi, M., Arts, J. J., & van Buul, J. D. (2023). ICAM-2 regulates diapedesis hotspots by allowing neutrophil crawling against the direction of flow. Vascular Biology (Bristol, England), VB-23.

Chen, J., Lin, X., He, J., Liu, D., He, L., Zhang, M., ... & Wang, Q. (2022). Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3‐mediated N6‐methyladenosine modification of ICAM2 mRNA in fibroblast‐like synoviocytes. Clinical and Translational Medicine, 12(12), e1148.

Echols, M., Deng, Z., Powers, C., Xiao, H., Zhu, Z., Lequio, M., ... & Fang, Y. (2022). SARS-CoV-2 Spike Protein Influences Expression of ICOSL and ICAM-2 in Prostate Cancer. Journal of Men's Health, 18(10), 201.

Chong, D. L., Rebeyrol, C., José, R. J., Williams, A. E., Brown, J. S., Scotton, C. J., & Porter, J. C. (2021). ICAM-1 and ICAM-2 are differentially expressed and up-regulated on inflamed pulmonary epithelium, but neither ICAM-2 nor LFA-1: ICAM-1 are required for neutrophil migration into the airways in vivo. Frontiers in Immunology, 12, 691957.

Haghayegh Jahromi, N., Marchetti, L., Moalli, F., Duc, D., Basso, C., Tardent, H., ... & Engelhardt, B. (2020). Intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 differentially contribute to peripheral activation and CNS entry of autoaggressive Th1 and Th17 cells in experimental autoimmune encephalomyelitis. Frontiers in immunology, 10, 3056.

Sun-sang, J. S. (2020). Co-immunostaining of ICAM-1, ICAM-2, and CD31 in Mouse Kidney Glomeruli. Bio-protocol, 10(13), e3663-e3663.

Demiryürek, S., Saracaloglu, A., Kimyon, S., Mete, A., Eronat, O., Temiz, E., ... & Demiryürek, A. T. (2019). Increased Expressions of ICAM-2 and ICAM-3 in Pterygium. Current eye research, 44(6), 645-650.

Jin, X., Bu, Q., Zou, Y., Feng, Y., & Wei, M. (2018). Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. Glycoconjugate journal, 35, 287-297.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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