ICAM2
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
Intercellular Adhesion Molecule 2
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Cell-cell adhesion Source: InterPro
Cellular Location
Membrane; Microvillus. Co-localizes with RDX, EZR and MSN in microvilli.
Topology
Extracellular: 25-223
Helical: 224-248
Cytoplasmic: 249-275
Helical: 224-248
Cytoplasmic: 249-275
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Anti-ICAM2 antibodies
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CompareTarget: ICAM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0546
Application*: E, F, IH
Target: ICAM2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 5K55
Application*: F, IH, IP
Target: ICAM2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 3C4
Application*: C, FN, P, F
Target: ICAM2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 10B512
Application*: F, IP
Target: ICAM2
Sensitivity: 0.13 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: ICAM2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-222
Tag: hFc Tag
Target: ICAM2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-222
Target: ICAM2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-223
Tag: His Tag
Target: ICAM2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-223
Tag: His & hFc Tag
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4421
Application*: IH, F
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3910
Application*: F
Target: ICAM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1600
Application*: WB: 1:500~1:1000 ELISA: 1:10000
Target: ICAM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D7P2Q
Application*: WB, IP, P, IF (IC), F
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBR-IC2/2
Application*: FC, IH, IP
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1795
Application*: FC, IP, WB
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-R7
Application*: E
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBRIC2/2
Application*: C, FN, IP, F
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-T1
Application*: E, IP, F, FN
Target: ICAM2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXC-1648
Application*: F, IH, IP
Target: ICAM2
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 3C4 (MIC2/4)
Application*: F, IH, IP
Target: ICAM2
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0935
Application*: F
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2542
Application*: F
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0525
Application*: F, IH, IP
Target: ICAM2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-C0467
Application*: F, IH, IP
Target: ICAM2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-2746
Application*: F
Target: ICAM2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0186
Application*: F, IP
Target: ICAM2
Host: Rabbit
Specificity: Human
Clone: CBYY-I1688
Application*: WB, IP, P, IF, F
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1097
Application*: P
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0784
Application*: WB
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0517
Application*: WB, F, IF, IP
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6D42
Application*: E, F, IH
Target: ICAM2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6A356
Application*: F, IH, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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