Human ICAM2 ELISA Kit (V2LY-0626-LY636)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.13 ng/mL
Detection Range
0.2-60 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
30.7 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Intercellular Adhesion Molecule 2
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Cellular Location
Membrane; Microvillus. Co-localizes with RDX, EZR and MSN in microvilli.
Topology
Extracellular: 25-223
Helical: 224-248
Cytoplasmic: 249-275

Pan, J. K., Lin, W. D., Kuo, Y. L., Chen, Y. C., Loh, Z. J., Lin, F. C., ... & Lu, P. J. (2023). ICAM2 initiates trans-blood-CSF barrier migration and stemness properties in leptomeningeal metastasis of triple-negative breast cancer. Oncogene, 1-13.

Grönloh, M. L., Tebbens, M. E., Kotsi, M., Arts, J. J., & van Buul, J. D. (2023). ICAM-2 regulates diapedesis hotspots by allowing neutrophil crawling against the direction of flow. Vascular Biology (Bristol, England), VB-23.

Chen, J., Lin, X., He, J., Liu, D., He, L., Zhang, M., ... & Wang, Q. (2022). Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3‐mediated N6‐methyladenosine modification of ICAM2 mRNA in fibroblast‐like synoviocytes. Clinical and Translational Medicine, 12(12), e1148.

Echols, M., Deng, Z., Powers, C., Xiao, H., Zhu, Z., Lequio, M., ... & Fang, Y. (2022). SARS-CoV-2 Spike Protein Influences Expression of ICOSL and ICAM-2 in Prostate Cancer. Journal of Men's Health, 18(10), 201.

Chong, D. L., Rebeyrol, C., José, R. J., Williams, A. E., Brown, J. S., Scotton, C. J., & Porter, J. C. (2021). ICAM-1 and ICAM-2 are differentially expressed and up-regulated on inflamed pulmonary epithelium, but neither ICAM-2 nor LFA-1: ICAM-1 are required for neutrophil migration into the airways in vivo. Frontiers in Immunology, 12, 691957.

Haghayegh Jahromi, N., Marchetti, L., Moalli, F., Duc, D., Basso, C., Tardent, H., ... & Engelhardt, B. (2020). Intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 differentially contribute to peripheral activation and CNS entry of autoaggressive Th1 and Th17 cells in experimental autoimmune encephalomyelitis. Frontiers in immunology, 10, 3056.

Sun-sang, J. S. (2020). Co-immunostaining of ICAM-1, ICAM-2, and CD31 in Mouse Kidney Glomeruli. Bio-protocol, 10(13), e3663-e3663.

Demiryürek, S., Saracaloglu, A., Kimyon, S., Mete, A., Eronat, O., Temiz, E., ... & Demiryürek, A. T. (2019). Increased Expressions of ICAM-2 and ICAM-3 in Pterygium. Current eye research, 44(6), 645-650.

Jin, X., Bu, Q., Zou, Y., Feng, Y., & Wei, M. (2018). Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. Glycoconjugate journal, 35, 287-297.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ICAM2 protein, His & hFc Tag (CAT#: V2LY-0526-LY4626)

Human Recombinant ICAM2 protein, His Tag (CAT#: V2LY-0526-LY4627)

Mouse Recombinant ICAM2 protein (CAT#: V2LY-0526-LY8416)

Mouse Recombinant ICAM2 protein, hFc Tag (CAT#: V2LY-0526-LY8417)

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Human Anti-ICAM2 Recombinant Antibody (CBXC-0935) (CAT#: CBMAB-C2051-CQ)

Mouse Anti-ICAM2 Recombinant Antibody (6D42) (CAT#: CBMAB-C8211-LY)

Mouse Anti-ICAM2 Recombinant Antibody (CBYY-C0525) (CAT#: CBMAB-C1565-YY)

Rat Anti-ICAM2 Recombinant Antibody (CBYY-C0467) (CAT#: CBMAB-C1425-YY)

Rabbit Anti-ICAM2 Recombinant Antibody (CBYY-I1688) (CAT#: CBMAB-I2858-YY)

Mouse Anti-ICAM2 Recombinant Antibody (6A356) (CAT#: CBMAB-C8016-LY)

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Mouse Anti-ICAM2 Recombinant Antibody (CBYY-I0517) (CAT#: CBMAB-I1182-YY)

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For research use only. Not intended for any clinical use.

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