Human Recombinant ICAM2 protein, His Tag (V2LY-0526-LY4627)

Name: Human Recombinant ICAM2 protein, His Tag
SKU: V2LY-0526-LY4627
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ICAM2 protein, His Tag consist of Amino Acid: 1-223 and predicts a molecular mass of 24 kDa.

Molecule Mass

24 kDa

Sequence

Amino Acid: 1-223

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Intercellular Adhesion Molecule 2

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Biological Process

Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro

Cellular Location

Membrane; Microvillus. Co-localizes with RDX, EZR and MSN in microvilli.

Topology

Extracellular: 25-223
Helical: 224-248
Cytoplasmic: 249-275

Pan, J. K., Lin, W. D., Kuo, Y. L., Chen, Y. C., Loh, Z. J., Lin, F. C., ... & Lu, P. J. (2023). ICAM2 initiates trans-blood-CSF barrier migration and stemness properties in leptomeningeal metastasis of triple-negative breast cancer. Oncogene, 1-13.

Grönloh, M. L., Tebbens, M. E., Kotsi, M., Arts, J. J., & van Buul, J. D. (2023). ICAM-2 regulates diapedesis hotspots by allowing neutrophil crawling against the direction of flow. Vascular Biology (Bristol, England), VB-23.

Chen, J., Lin, X., He, J., Liu, D., He, L., Zhang, M., ... & Wang, Q. (2022). Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3‐mediated N6‐methyladenosine modification of ICAM2 mRNA in fibroblast‐like synoviocytes. Clinical and Translational Medicine, 12(12), e1148.

Echols, M., Deng, Z., Powers, C., Xiao, H., Zhu, Z., Lequio, M., ... & Fang, Y. (2022). SARS-CoV-2 Spike Protein Influences Expression of ICOSL and ICAM-2 in Prostate Cancer. Journal of Men's Health, 18(10), 201.

Chong, D. L., Rebeyrol, C., José, R. J., Williams, A. E., Brown, J. S., Scotton, C. J., & Porter, J. C. (2021). ICAM-1 and ICAM-2 are differentially expressed and up-regulated on inflamed pulmonary epithelium, but neither ICAM-2 nor LFA-1: ICAM-1 are required for neutrophil migration into the airways in vivo. Frontiers in Immunology, 12, 691957.

Haghayegh Jahromi, N., Marchetti, L., Moalli, F., Duc, D., Basso, C., Tardent, H., ... & Engelhardt, B. (2020). Intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 differentially contribute to peripheral activation and CNS entry of autoaggressive Th1 and Th17 cells in experimental autoimmune encephalomyelitis. Frontiers in immunology, 10, 3056.

Sun-sang, J. S. (2020). Co-immunostaining of ICAM-1, ICAM-2, and CD31 in Mouse Kidney Glomeruli. Bio-protocol, 10(13), e3663-e3663.

Demiryürek, S., Saracaloglu, A., Kimyon, S., Mete, A., Eronat, O., Temiz, E., ... & Demiryürek, A. T. (2019). Increased Expressions of ICAM-2 and ICAM-3 in Pterygium. Current eye research, 44(6), 645-650.

Jin, X., Bu, Q., Zou, Y., Feng, Y., & Wei, M. (2018). Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions. Glycoconjugate journal, 35, 287-297.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ICAM2 protein, His & hFc Tag (CAT#: V2LY-0526-LY4626)

Mouse Recombinant ICAM2 protein (CAT#: V2LY-0526-LY8416)

Mouse Recombinant ICAM2 protein, hFc Tag (CAT#: V2LY-0526-LY8417)

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Mouse Recombinant ICAM2 protein (CAT#: V2LY-0526-LY8416)

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Rat Anti-ICAM2 Recombinant Antibody (3C4) (CAT#: CBMAB-C1090-LY)

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Mouse Recombinant ICAM2 protein, hFc Tag (CAT#: V2LY-0526-LY8417)

Human Recombinant ICAM2 protein, His & hFc Tag (CAT#: V2LY-0526-LY4626)

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Isotype control

For research use only. Not intended for any clinical use.

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