Sign in or Register   Sign in or Register
  |  

Rat Anti-ICAM5 Monoclonal Antibody (191321) (CBMAB-1354-YC)

Provided herein is a rat monoclonal antibody against Human ICAM5. The antibody, clone 191321, can be used for immunoassay techniques, such as WB.
See all ICAM5 antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
191321
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse ICAM‑5 Leu31-Arg828 (Pro47Arg).
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Intercellular Adhesion Molecule 5
Introduction
ICAM5 is a member of the intercellular adhesion molecule (ICAM) family, which is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. ICAM5 may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.
Entrez Gene ID
7087
UniProt ID
Q9UMF0
Alternative Names
TLN; TLCN
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Phagocytosis Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 32-835
Helical: 836-856
Cytoplasmic: 857-924
PTM
Glycosylation at Asn-54 is critical for functional folding.

Shen, Y., Xie, X., Bai, X., Bai, H., Chang, X., Tang, Y., & Li, Q. (2021). Study on the Protective Mechanism of Acupuncture Regulating ICAM-5 mRNA Expression in Rats with Ischemic Stroke. Journal of Behavioral and Brain Science, 11(12), 313-321.

Jiang, Y., Liu, S., Shen, S., Guo, H., Huang, H., & Wei, W. (2020). Methyl-β-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts. Antiviral Research, 176, 104752.

Pei, Y. P., Wang, Y. Y., Liu, D., Lei, H. Y., Yang, Z. H., Zhang, Z. W., ... & Zeng, Y. (2020). ICAM5 as a novel target for treating cognitive impairment in fragile X syndrome. Journal of Neuroscience, 40(6), 1355-1365.

Birkner, K., Loos, J., Gollan, R., Steffen, F., Wasser, B., Ruck, T., ... & Bittner, S. (2019). Neuronal ICAM-5 plays a neuroprotective role in progressive neurodegeneration. Frontiers in neurology, 10, 205.

Cheng, K., Chen, Y. S., Yue, C. X., Zhang, S. M., Pei, Y. P., Cheng, G. R., ... & Zeng, Y. (2019). Calsyntenin-1 negatively regulates ICAM5 accumulation in postsynaptic membrane and influences dendritic spine maturation in a mouse model of fragile X syndrome. Frontiers in Neuroscience, 13, 1098.

Dütsch, M., Blossey, P. N., Steig, E. J., & Nusbaumer, J. M. (2019). Nonequilibrium fractionation during ice cloud formation in iCAM5: Evaluating the common parameterization of supersaturation as a linear function of temperature. Journal of Advances in Modeling Earth Systems, 11(11), 3777-3793.

Wingo, A., Daskalakis, N., Galatzer-Levy, I., Richholt, R., Michopoulos, V., Lori, A., ... & Ressler, K. (2018). 228. Transcriptome-Wide Analysis Identifies ICAM5 Differentially Expressed in Chronic PTSD Symptoms Versus Resiliency Post Trauma Exposure in a Longitudinal Study. Biological Psychiatry, 83(9), S91-S92.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-ICAM5 Monoclonal Antibody (191321)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare