ICAM5

ICAM5 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. It is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.

Intercellular Adhesion Molecule 5

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Phagocytosis Source: Ensembl

Membrane

Extracellular: 32-835
Helical: 836-856
Cytoplasmic: 857-924

Glycosylation at Asn-54 is critical for functional folding.