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Mouse Anti-ICAM5 Recombinant Antibody (CBYJT-1386) (CBMAB-T0408-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to ICAM5 (Intercellular Adhesion Molecule 5). The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all ICAM5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1386
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Intercellular Adhesion Molecule 5
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Intercellular Adhesion Molecule 5
Introduction
ICAM5 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. It is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.
Entrez Gene ID
7087
UniProt ID
Q9UMF0
Alternative Names
Intercellular Adhesion Molecule 5
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).
Biological Process
Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Phagocytosis Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 32-835
Helical: 836-856
Cytoplasmic: 857-924
PTM
Glycosylation at Asn-54 is critical for functional folding.

Shen, Y., Xie, X., Bai, X., Bai, H., Chang, X., Tang, Y., & Li, Q. (2021). Study on the Protective Mechanism of Acupuncture Regulating ICAM-5 mRNA Expression in Rats with Ischemic Stroke. Journal of Behavioral and Brain Science, 11(12), 313-321.

Jiang, Y., Liu, S., Shen, S., Guo, H., Huang, H., & Wei, W. (2020). Methyl-β-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts. Antiviral Research, 176, 104752.

Pei, Y. P., Wang, Y. Y., Liu, D., Lei, H. Y., Yang, Z. H., Zhang, Z. W., ... & Zeng, Y. (2020). ICAM5 as a novel target for treating cognitive impairment in fragile X syndrome. Journal of Neuroscience, 40(6), 1355-1365.

Birkner, K., Loos, J., Gollan, R., Steffen, F., Wasser, B., Ruck, T., ... & Bittner, S. (2019). Neuronal ICAM-5 plays a neuroprotective role in progressive neurodegeneration. Frontiers in neurology, 10, 205.

Cheng, K., Chen, Y. S., Yue, C. X., Zhang, S. M., Pei, Y. P., Cheng, G. R., ... & Zeng, Y. (2019). Calsyntenin-1 negatively regulates ICAM5 accumulation in postsynaptic membrane and influences dendritic spine maturation in a mouse model of fragile X syndrome. Frontiers in Neuroscience, 13, 1098.

Dütsch, M., Blossey, P. N., Steig, E. J., & Nusbaumer, J. M. (2019). Nonequilibrium fractionation during ice cloud formation in iCAM5: Evaluating the common parameterization of supersaturation as a linear function of temperature. Journal of Advances in Modeling Earth Systems, 11(11), 3777-3793.

Wingo, A., Daskalakis, N., Galatzer-Levy, I., Richholt, R., Michopoulos, V., Lori, A., ... & Ressler, K. (2018). 228. Transcriptome-Wide Analysis Identifies ICAM5 Differentially Expressed in Chronic PTSD Symptoms Versus Resiliency Post Trauma Exposure in a Longitudinal Study. Biological Psychiatry, 83(9), S91-S92.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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