Human Recombinant ICAM5 protein, ECD, hFc Tag (V2LY-0526-LY4630)

Name: Human Recombinant ICAM5 protein, ECD, hFc Tag
SKU: V2LY-0526-LY4630
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant ICAM5 protein, ECD, hFc Tag consist of Amino Acid: 1-570 and predicts a molecular mass of 84.9 kDa.

Molecule Mass

84.9 kDa

Protein Domain

ECD

Sequence

Amino Acid: 1-570

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Intercellular Adhesion Molecule 5

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

Biological Process

Cell adhesion Source: GO_Central
Cell-cell adhesion Source: InterPro
Phagocytosis Source: Ensembl

Cellular Location

Membrane

Topology

Extracellular: 32-835
Helical: 836-856
Cytoplasmic: 857-924

PTM

Glycosylation at Asn-54 is critical for functional folding.

Shen, Y., Xie, X., Bai, X., Bai, H., Chang, X., Tang, Y., & Li, Q. (2021). Study on the Protective Mechanism of Acupuncture Regulating ICAM-5 mRNA Expression in Rats with Ischemic Stroke. Journal of Behavioral and Brain Science, 11(12), 313-321.

Jiang, Y., Liu, S., Shen, S., Guo, H., Huang, H., & Wei, W. (2020). Methyl-β-cyclodextrin inhibits EV-D68 virus entry by perturbing the accumulation of virus particles and ICAM-5 in lipid rafts. Antiviral Research, 176, 104752.

Pei, Y. P., Wang, Y. Y., Liu, D., Lei, H. Y., Yang, Z. H., Zhang, Z. W., ... & Zeng, Y. (2020). ICAM5 as a novel target for treating cognitive impairment in fragile X syndrome. Journal of Neuroscience, 40(6), 1355-1365.

Birkner, K., Loos, J., Gollan, R., Steffen, F., Wasser, B., Ruck, T., ... & Bittner, S. (2019). Neuronal ICAM-5 plays a neuroprotective role in progressive neurodegeneration. Frontiers in neurology, 10, 205.

Cheng, K., Chen, Y. S., Yue, C. X., Zhang, S. M., Pei, Y. P., Cheng, G. R., ... & Zeng, Y. (2019). Calsyntenin-1 negatively regulates ICAM5 accumulation in postsynaptic membrane and influences dendritic spine maturation in a mouse model of fragile X syndrome. Frontiers in Neuroscience, 13, 1098.

Dütsch, M., Blossey, P. N., Steig, E. J., & Nusbaumer, J. M. (2019). Nonequilibrium fractionation during ice cloud formation in iCAM5: Evaluating the common parameterization of supersaturation as a linear function of temperature. Journal of Advances in Modeling Earth Systems, 11(11), 3777-3793.

Wingo, A., Daskalakis, N., Galatzer-Levy, I., Richholt, R., Michopoulos, V., Lori, A., ... & Ressler, K. (2018). 228. Transcriptome-Wide Analysis Identifies ICAM5 Differentially Expressed in Chronic PTSD Symptoms Versus Resiliency Post Trauma Exposure in a Longitudinal Study. Biological Psychiatry, 83(9), S91-S92.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ICAM5 protein, ECD, His Tag (CAT#: V2LY-0526-LY4631)

Human Recombinant ICAM5 protein, hFc Tag (CAT#: V2LY-0526-LY4632)

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Human Recombinant ICAM5 protein, ECD, His Tag (CAT#: V2LY-0526-LY4631)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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