Mouse Anti-IFI6 Recombinant Antibody (M2) (CBMAB-I0818-YY)

Name: Mouse Anti-IFI6 Recombinant Antibody (M2)
SKU: CBMAB-I0818-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Application

ELISA

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interferon Alpha Inducible Protein 6

Introduction

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.

Entrez Gene ID

2537

UniProt ID

P09912

Alternative Names

Interferon Alpha Inducible Protein 6

Function

Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642).

However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746).

Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed:25757571).

Biological Process

Apoptotic process Source: UniProtKB
Apoptotic signaling pathway Source: GO_Central
Cellular response to virus Source: UniProtKB
Defense response to virus Source: UniProtKB
Immune response Source: ProtInc
Innate immune response Source: UniProtKB
Intrinsic apoptotic signaling pathway Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
Negative regulation of mitochondrial depolarization Source: HGNC-UCL
Reactive oxygen species metabolic process Source: UniProtKB
Regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Release of cytochrome c from mitochondria Source: HGNC-UCL

Cellular Location

Mitochondrion inner membrane

PTM

Glycosylated.

Villamayor, L., Rivero, V., López-García, D., Topham, D. J., Martínez-Sobrido, L., Nogales, A., & DeDiego, M. L. (2023). Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation. Frontiers in immunology, 14, 1105309.

Park, J. W., Ndimukaga, M., So, J., Kim, S., Truong, A. D., Tran, H. T. T., ... & Song, K. D. (2023). Molecular analysis of chicken interferon-alpha inducible protein 6 gene and transcriptional regulation. Journal of Animal Science and Technology, 65(1), 183.

Lǚ, K., Li, H., Wang, S., Li, A., Weng, S., He, J., & Li, C. (2022). Interferon-induced protein 6-16 (IFI6-16) from Litopenaeus vannamei regulate antiviral immunity via apoptosis-related genes. Viruses, 14(5), 1062.

Sajid, M., Ullah, H., Yan, K., He, M., Feng, J., Shereen, M. A., ... & Zhou, L. (2021). The functional and antiviral activity of interferon alpha-inducible IFI6 against hepatitis B virus replication and gene expression. Frontiers in Immunology, 12, 634937.

Jia, H., Mo, W., Hong, M., Jiang, S., Zhang, Y. Y., He, D., ... & Zhang, S. (2020). Interferon-α inducible protein 6 (IFI6) confers protection against ionizing radiation in skin cells. Journal of Dermatological Science, 100(2), 139-147.

Liu, X., Duan, X., Holmes, J. A., Li, W., Lee, S. H., Tu, Z., ... & Chung, R. T. (2019). A long noncoding RNA regulates hepatitis C virus infection through interferon alpha–inducible protein 6. Hepatology, 69(3), 1004-1019.

Richardson, R. B., Ohlson, M. B., Eitson, J. L., Kumar, A., McDougal, M. B., Boys, I. N., ... & Schoggins, J. W. (2018). A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication. Nature microbiology, 3(11), 1214-1223.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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