Human IFI6 ELISA Kit (V2LY-0626-LY4744)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.0077 ng/mL
Detection Range
0.015-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
12.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Interferon Alpha Inducible Protein 6
Function
Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642).

However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746).

Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed:25757571).
Biological Process
Apoptotic process Source: UniProtKB
Apoptotic signaling pathway Source: GO_Central
Cellular response to virus Source: UniProtKB
Defense response to virus Source: UniProtKB
Immune response Source: ProtInc
Innate immune response Source: UniProtKB
Intrinsic apoptotic signaling pathway Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
Negative regulation of mitochondrial depolarization Source: HGNC-UCL
Reactive oxygen species metabolic process Source: UniProtKB
Regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Release of cytochrome c from mitochondria Source: HGNC-UCL
Cellular Location
Mitochondrion inner membrane
PTM
Glycosylated.

Villamayor, L., Rivero, V., López-García, D., Topham, D. J., Martínez-Sobrido, L., Nogales, A., & DeDiego, M. L. (2023). Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation. Frontiers in immunology, 14, 1105309.

Park, J. W., Ndimukaga, M., So, J., Kim, S., Truong, A. D., Tran, H. T. T., ... & Song, K. D. (2023). Molecular analysis of chicken interferon-alpha inducible protein 6 gene and transcriptional regulation. Journal of Animal Science and Technology, 65(1), 183.

Lǚ, K., Li, H., Wang, S., Li, A., Weng, S., He, J., & Li, C. (2022). Interferon-induced protein 6-16 (IFI6-16) from Litopenaeus vannamei regulate antiviral immunity via apoptosis-related genes. Viruses, 14(5), 1062.

Sajid, M., Ullah, H., Yan, K., He, M., Feng, J., Shereen, M. A., ... & Zhou, L. (2021). The functional and antiviral activity of interferon alpha-inducible IFI6 against hepatitis B virus replication and gene expression. Frontiers in Immunology, 12, 634937.

Jia, H., Mo, W., Hong, M., Jiang, S., Zhang, Y. Y., He, D., ... & Zhang, S. (2020). Interferon-α inducible protein 6 (IFI6) confers protection against ionizing radiation in skin cells. Journal of Dermatological Science, 100(2), 139-147.

Liu, X., Duan, X., Holmes, J. A., Li, W., Lee, S. H., Tu, Z., ... & Chung, R. T. (2019). A long noncoding RNA regulates hepatitis C virus infection through interferon alpha–inducible protein 6. Hepatology, 69(3), 1004-1019.

Richardson, R. B., Ohlson, M. B., Eitson, J. L., Kumar, A., McDougal, M. B., Boys, I. N., ... & Schoggins, J. W. (2018). A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication. Nature microbiology, 3(11), 1214-1223.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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