IFI6

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.

Full Name

Interferon Alpha Inducible Protein 6

Function

Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642).

However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746).

Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed:25757571).

Biological Process

Apoptotic process Source: UniProtKB
Apoptotic signaling pathway Source: GO_Central
Cellular response to virus Source: UniProtKB
Defense response to virus Source: UniProtKB
Immune response Source: ProtInc
Innate immune response Source: UniProtKB
Intrinsic apoptotic signaling pathway Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC-UCL
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
Negative regulation of mitochondrial depolarization Source: HGNC-UCL
Reactive oxygen species metabolic process Source: UniProtKB
Regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
Release of cytochrome c from mitochondria Source: HGNC-UCL

Cellular Location

Mitochondrion inner membrane

PTM

Glycosylated.