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Mouse Anti-IFIT3 Recombinant Antibody (1G1) (CBMAB-I0256-YY)

This product is Mouse antibody that recognizes IFIT3. The antibody 1G1 can be used for immunoassay techniques such as: WB, FC, IHC, IF, IHC-P, ICC, FC
See all IFIT3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
1G1
Antibody Isotype
IgG1
Application
WB, FC, IHC, IF, IHC-P, ICC, FC

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interferon Induced Protein With Tetratricopeptide Repeats 3
Introduction
IFIT3 (Interferon Induced Protein With Tetratricopeptide Repeats 3) is a Protein Coding gene. Diseases associated with IFIT3 include Systemic Lupus Erythematosus. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System.
Entrez Gene ID
Human3437
Monkey695344
UniProt ID
HumanO14879
MonkeyB6CJY5
Alternative Names
Interferon Induced Protein With Tetratricopeptide Repeats 3
Function
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Biological Process
Cellular response to interferon-alpha Source: InterPro
Defense response to virus Source: GO_Central
Innate immune response Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Response to virus Source: UniProtKB
Cellular Location
Cytoplasm; Mitochondrion

Zhang, W., Li, Y., Xin, S., Yang, L., Jiang, M., Xin, Y., ... & Lu, J. (2023). The emerging roles of IFIT3 in antiviral innate immunity and cellular biology. Journal of Medical Virology, 95(1), e28259.

Schindewolf, C., Lokugamage, K., Vu, M. N., Johnson, B. A., Scharton, D., Plante, J. A., ... & Menachery, V. D. (2023). SARS-CoV-2 uses nonstructural protein 16 to evade restriction by IFIT1 and IFIT3. Journal of virology, 97(2), e01532-22.

Wu, Y., Song, X., Cui, D., & Zhang, T. (2022). IFIT3 and IFIT5 play potential roles in innate immune response of porcine pulmonary microvascular endothelial cells to highly pathogenic porcine reproductive and respiratory syndrome virus. Viruses, 14(9), 1919.

Chai, B., Tian, D., Zhou, M., Tian, B., Yuan, Y., Sui, B., ... & Zhao, L. (2021). Murine Ifit3 restricts the replication of Rabies virus both in vitro and in vivo. Journal of General Virology, 102(7), 001619.

Chikhalya, A., Dittmann, M., Zheng, Y., Sohn, S. Y., Rice, C. M., & Hearing, P. (2021). Human IFIT3 protein induces interferon signaling and inhibits adenovirus immediate early gene expression. Mbio, 12(6), e02829-21.

Wang, Z., Qin, J., Zhao, J., Li, J., Li, D., Popp, M., ... & Bruns, C. J. (2020). Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer. Theranostics, 10(16), 7178.

Xu, F., Song, H., An, B., Xiao, Q., Cheng, G., & Tan, G. (2019). NF-κB-dependent IFIT3 induction by HBx promotes hepatitis B virus replication. Frontiers in microbiology, 10, 2382.

Pidugu, V. K., Wu, M. M., Yen, A. H., Pidugu, H. B., Chang, K. W., Liu, C. J., & Lee, T. C. (2019). IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling. Oncogene, 38(17), 3232-3247.

Fleith, R. C., Mears, H. V., Leong, X. Y., Sanford, T. J., Emmott, E., Graham, S. C., ... & Sweeney, T. R. (2018). IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA. Nucleic acids research, 46(10), 5269-5285.

Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., ... & Amarasinghe, G. K. (2018). Human IFIT3 modulates IFIT1 RNA binding specificity and protein stability. Immunity, 48(3), 487-499.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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