Sign in or Register   Sign in or Register
  |  

Mouse Anti-IFT57 Recombinant Antibody (3G4) (CBMAB-A4292-LY)

The product is antibody recognizes IFT57. The antibody 3G4 immunoassay techniques such as: WB, ELISA.
See all IFT57 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
IFT57 (NP_060480, 214 a.a. ~ 312 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Intraflagellar transport protein p57/55
Entrez Gene ID
55081
UniProt ID
Q9NWB7
Alternative Names
ESRRBL1; FLJ10147; HIPPI; MHS4R2
Function
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity).

Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
Apoptotic process Source: MGI
Heart looping Source: Ensembl
Intraciliary transport Source: GO_Central
Left/right pattern formation Source: Ensembl
Motile cilium assembly Source: Ensembl
Negative regulation of epithelial cell proliferation Source: Ensembl
Neural tube closure Source: Ensembl
Non-motile cilium assembly Source: GO_Central
Regulation of apoptotic process Source: MGI
Smoothened signaling pathway Source: Ensembl
Cellular Location
Cilium basal body. Concentrates within the inner segment of cilia.
Involvement in disease
Orofaciodigital syndrome 18 (OFD18):
A form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD18 is an autosomal recessive form characterized by short stature, brachymesophalangy, pre- and postaxial polysyndactyly, and stocky femoral necks, as well as oral anomalies and dysmorphic facial features.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-IFT57 Recombinant Antibody (3G4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare