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Mouse Anti-IFT57 Antibody (IFT57.1) (CBMAB-1337CQ)

This product is a mouse antibody that recognizes IFT57. The antibody IFT57.1 can be used for immunoassay techniques such as: WB.
See all IFT57 antibodies

Summary

Host Animal
Mouse
Specificity
Chlamydomonas
Clone
IFT57.1
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified intraflagellar transport complexes A and B
Specificity
Chlamydomonas
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Intraflagellar transport protein p57/55
Introduction
IFT is responsible for the assembly and maintenance of cilia and flagella; anterograde IFT is associated with the kinesin-2 motor, whereas retrograde IFT is associated with the dynein 1b motor.
Entrez Gene ID
UniProt ID
Alternative Names
IFT57; Intraflagellar transport protein p57/55
Function
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity).

Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
Apoptotic process Source: MGI
Heart looping Source: Ensembl
Intraciliary transport Source: GO_Central
Left/right pattern formation Source: Ensembl
Motile cilium assembly Source: Ensembl
Negative regulation of epithelial cell proliferation Source: Ensembl
Neural tube closure Source: Ensembl
Non-motile cilium assembly Source: GO_Central
Regulation of apoptotic process Source: MGI
Smoothened signaling pathway Source: Ensembl
Cellular Location
Cilium basal body. Concentrates within the inner segment of cilia.
Involvement in disease
Orofaciodigital syndrome 18 (OFD18):
A form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD18 is an autosomal recessive form characterized by short stature, brachymesophalangy, pre- and postaxial polysyndactyly, and stocky femoral necks, as well as oral anomalies and dysmorphic facial features.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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