Mouse Anti-IGFBP2 Recombinant Antibody (1.A.16) (CBMAB-I0090-YY)

Name: Mouse Anti-IGFBP2 Recombinant Antibody (1.A.16)
SKU: CBMAB-I0090-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1.A.16

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1M Tris HCl, pH 7.5

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Insulin Like Growth Factor Binding Protein 2

Introduction

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene.

Entrez Gene ID

3485

UniProt ID

P18065

Alternative Names

Insulin Like Growth Factor Binding Protein 2

Function

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Biological Process

Aging Source: Ensembl
Cellular response to hormone stimulus Source: Ensembl
Female pregnancy Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of activated T cell proliferation Source: BHF-UCL
Regulation of growth Source: UniProtKB-KW
Regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
Response to estradiol Source: Ensembl
Response to estrogen Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to lithium ion Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to nutrient Source: Ensembl
Response to retinoic acid Source: Ensembl
Response to xenobiotic stimulus Source: Ensembl
Signal transduction Source: Ensembl

Cellular Location

Secreted

PTM

O-glycosylated.

Zhang, B., Hong, C. Q., Luo, Y. H., Wei, L. F., Luo, Y., Peng, Y. H., & Xu, Y. W. (2022). Prognostic value of IGFBP2 in various cancers: a systematic review and meta‐analysis. Cancer Medicine, 11(16), 3035-3047.

Sun, L., Zhang, X., Song, Q., Liu, L., Forbes, E., Tian, W., ... & Zhang, W. (2021). IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway. Cancer letters, 500, 132-146.

Wei, L. F., Weng, X. F., Huang, X. C., Peng, Y. H., Guo, H. P., & Xu, Y. W. (2021). IGFBP2 in cancer: Pathological role and clinical significance. Oncology Reports, 45(2), 427-438.

Masuo, K., Chen, R., Yogo, A., Sugiyama, A., Fukuda, A., Masui, T., ... & Takaishi, S. (2021). SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2. Cancer Science, 112(12), 4987-4999.

Li, T., Forbes, M. E., Fuller, G. N., Li, J., Yang, X., & Zhang, W. (2020). IGFBP2: integrative hub of developmental and oncogenic signaling network. Oncogene, 39(11), 2243-2257.

Fahlbusch, P., Knebel, B., Hörbelt, T., Barbosa, D. M., Nikolic, A., Jacob, S., ... & Kotzka, J. (2020). Physiological disturbance in fatty liver energy metabolism converges on IGFBP2 abundance and regulation in mice and men. International journal of molecular sciences, 21(11), 4144.

Li, T., Zhang, C., Zhao, G., Zhang, X., Hao, M., Hassan, S., ... & Yang, J. (2020). IGFBP2 regulates PD-L1 expression by activating the EGFR-STAT3 signaling pathway in malignant melanoma. Cancer letters, 477, 19-30.

Liu, Y., Li, F., Yang, Y. T., Xu, X. D., Chen, J. S., Chen, T. L., ... & Ke, Y. Q. (2019). IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma. Oncogene, 38(11), 1815-1831.

Khan, S., Lu, X., Huang, Q., Tang, J., Weng, J., Yang, Z., ... & Chen, X. (2019). IGFBP2 plays an essential role in cognitive development during early life. Advanced Science, 6(23), 1901152.

Cai, J., Chen, Q., Cui, Y., Dong, J., Chen, M., Wu, P., & Jiang, C. (2018). Immune heterogeneity and clinicopathologic characterization of IGFBP2 in 2447 glioma samples. Oncoimmunology, 7(5), e1426516.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

IGFBP2 Matched Antibody Pair (607) (CAT#: APMAB-607LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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