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IGFBP2 Matched Antibody Pair (607) (APMAB-607LY)

This antibody pair set can be used for detecting and quantifying protein level of human IGFBP2.
See all IGFBP2 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IGFBP2 polyclonal antibody, 100 ug
Detection Antibody
Anti-IGFBP2 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
Alternative Names
Insulin Like Growth Factor Binding Protein 2
Entrez Gene ID
3485
UniProt ID
P18065

Zhang, B., Hong, C. Q., Luo, Y. H., Wei, L. F., Luo, Y., Peng, Y. H., & Xu, Y. W. (2022). Prognostic value of IGFBP2 in various cancers: a systematic review and meta‐analysis. Cancer Medicine, 11(16), 3035-3047.

Sun, L., Zhang, X., Song, Q., Liu, L., Forbes, E., Tian, W., ... & Zhang, W. (2021). IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway. Cancer letters, 500, 132-146.

Wei, L. F., Weng, X. F., Huang, X. C., Peng, Y. H., Guo, H. P., & Xu, Y. W. (2021). IGFBP2 in cancer: Pathological role and clinical significance. Oncology Reports, 45(2), 427-438.

Masuo, K., Chen, R., Yogo, A., Sugiyama, A., Fukuda, A., Masui, T., ... & Takaishi, S. (2021). SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2. Cancer Science, 112(12), 4987-4999.

Li, T., Forbes, M. E., Fuller, G. N., Li, J., Yang, X., & Zhang, W. (2020). IGFBP2: integrative hub of developmental and oncogenic signaling network. Oncogene, 39(11), 2243-2257.

Fahlbusch, P., Knebel, B., Hörbelt, T., Barbosa, D. M., Nikolic, A., Jacob, S., ... & Kotzka, J. (2020). Physiological disturbance in fatty liver energy metabolism converges on IGFBP2 abundance and regulation in mice and men. International journal of molecular sciences, 21(11), 4144.

Li, T., Zhang, C., Zhao, G., Zhang, X., Hao, M., Hassan, S., ... & Yang, J. (2020). IGFBP2 regulates PD-L1 expression by activating the EGFR-STAT3 signaling pathway in malignant melanoma. Cancer letters, 477, 19-30.

Liu, Y., Li, F., Yang, Y. T., Xu, X. D., Chen, J. S., Chen, T. L., ... & Ke, Y. Q. (2019). IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma. Oncogene, 38(11), 1815-1831.

Khan, S., Lu, X., Huang, Q., Tang, J., Weng, J., Yang, Z., ... & Chen, X. (2019). IGFBP2 plays an essential role in cognitive development during early life. Advanced Science, 6(23), 1901152.

Cai, J., Chen, Q., Cui, Y., Dong, J., Chen, M., Wu, P., & Jiang, C. (2018). Immune heterogeneity and clinicopathologic characterization of IGFBP2 in 2447 glioma samples. Oncoimmunology, 7(5), e1426516.

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For research use only. Not intended for any clinical use.

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