Rhesus Recombinant IGFBP2 protein, His Tag (V2LY-0526-LY9731)

Name: Rhesus Recombinant IGFBP2 protein, His Tag
SKU: V2LY-0526-LY9731
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rhesus

Tag

His Tag

Protein Construction

This product is Rhesus Recombinant IGFBP2 protein, His Tag consist of Amino Acid: 1-324 and predicts a molecular mass of 32.8 kDa.

Molecule Mass

32.8 kDa

Sequence

Amino Acid: 1-324

Species

Rhesus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>67% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Insulin Like Growth Factor Binding Protein 2

Function

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Biological Process

Aging Source: Ensembl
Cellular response to hormone stimulus Source: Ensembl
Female pregnancy Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of activated T cell proliferation Source: BHF-UCL
Regulation of growth Source: UniProtKB-KW
Regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
Response to estradiol Source: Ensembl
Response to estrogen Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to lithium ion Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to nutrient Source: Ensembl
Response to retinoic acid Source: Ensembl
Response to xenobiotic stimulus Source: Ensembl
Signal transduction Source: Ensembl

Cellular Location

Secreted

PTM

O-glycosylated.

Zhang, B., Hong, C. Q., Luo, Y. H., Wei, L. F., Luo, Y., Peng, Y. H., & Xu, Y. W. (2022). Prognostic value of IGFBP2 in various cancers: a systematic review and meta‐analysis. Cancer Medicine, 11(16), 3035-3047.

Sun, L., Zhang, X., Song, Q., Liu, L., Forbes, E., Tian, W., ... & Zhang, W. (2021). IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway. Cancer letters, 500, 132-146.

Wei, L. F., Weng, X. F., Huang, X. C., Peng, Y. H., Guo, H. P., & Xu, Y. W. (2021). IGFBP2 in cancer: Pathological role and clinical significance. Oncology Reports, 45(2), 427-438.

Masuo, K., Chen, R., Yogo, A., Sugiyama, A., Fukuda, A., Masui, T., ... & Takaishi, S. (2021). SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2. Cancer Science, 112(12), 4987-4999.

Li, T., Forbes, M. E., Fuller, G. N., Li, J., Yang, X., & Zhang, W. (2020). IGFBP2: integrative hub of developmental and oncogenic signaling network. Oncogene, 39(11), 2243-2257.

Fahlbusch, P., Knebel, B., Hörbelt, T., Barbosa, D. M., Nikolic, A., Jacob, S., ... & Kotzka, J. (2020). Physiological disturbance in fatty liver energy metabolism converges on IGFBP2 abundance and regulation in mice and men. International journal of molecular sciences, 21(11), 4144.

Li, T., Zhang, C., Zhao, G., Zhang, X., Hao, M., Hassan, S., ... & Yang, J. (2020). IGFBP2 regulates PD-L1 expression by activating the EGFR-STAT3 signaling pathway in malignant melanoma. Cancer letters, 477, 19-30.

Liu, Y., Li, F., Yang, Y. T., Xu, X. D., Chen, J. S., Chen, T. L., ... & Ke, Y. Q. (2019). IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma. Oncogene, 38(11), 1815-1831.

Khan, S., Lu, X., Huang, Q., Tang, J., Weng, J., Yang, Z., ... & Chen, X. (2019). IGFBP2 plays an essential role in cognitive development during early life. Advanced Science, 6(23), 1901152.

Cai, J., Chen, Q., Cui, Y., Dong, J., Chen, M., Wu, P., & Jiang, C. (2018). Immune heterogeneity and clinicopathologic characterization of IGFBP2 in 2447 glioma samples. Oncoimmunology, 7(5), e1426516.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant IGFBP2 protein, hFc Tag (CAT#: V2LY-0526-LY8439)

Mouse Recombinant IGFBP2 protein, His Tag (CAT#: V2LY-0526-LY8440)

Cattle IGFBP2 ELISA Kit (CAT#: V2LY-0626-LY3)

Mouse Igfbp2 ELISA Kit (CAT#: V2LY-0626-LY582)

Pig IGFBP2 ELISA Kit (CAT#: V2LY-0626-LY673)

Human IGFBP2 ELISA Kit (CAT#: V2LY-0626-LY837)

IGFBP2 Matched Antibody Pair (607) (CAT#: APMAB-607LY)

Antibody Pairs

IGFBP2 Matched Antibody Pair (607) (CAT#: APMAB-607LY)

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Cattle IGFBP2 ELISA Kit (CAT#: V2LY-0626-LY3)

IGFBP2 Matched Antibody Pair (607) (CAT#: APMAB-607LY)

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Mouse Anti-IGFBP2 Recombinant Antibody (CBT3501) (CAT#: V2LY-0625-LY2241)

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Rat Anti-IGFBP2 Recombinant Antibody (8J27) (CAT#: CBMAB-I1782-YY)

Mouse Anti-IGFBP2 Recombinant Antibody (1.A.16) (CAT#: CBMAB-I0090-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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