Mouse Anti-IL11RA Recombinant Antibody (3D4-G4) (CBMAB-A4325-LY)

Name: Mouse Anti-IL11RA Recombinant Antibody (3D4-G4)
SKU: CBMAB-A4325-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3D4-G4

Application

WB, ELISA

Immunogen

IL11RA (AAH03110, 1 a.a. ~ 422 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 11 Receptor Subunit Alpha

Introduction

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. [provided by RefSeq]

Entrez Gene ID

3590

UniProt ID

Q14626

Alternative Names

MGC2146

Function

Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.

Soluble interleukin-11 receptor subunit alpha:
Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177).

The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:30279168, PubMed:26876177).

Isoform HCR2:
Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177).

The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:30279168, PubMed:26876177).

Biological Process

Cytokine-mediated signaling pathway Source: GO_Central
Developmental process Source: UniProtKB
Head development Source: UniProtKB
Positive regulation of cell population proliferation Source: GO_Central

Cellular Location

Interleukin-11 receptor subunit alpha: Membrane
Soluble interleukin-11 receptor subunit alpha: Secreted
Isoform HCR2: Secreted

Involvement in disease

Craniosynostosis and dental anomalies (CRSDA):
A disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.

Topology

Extracellular: 24-370
Helical: 371-391
Cytoplasmic: 392-422

PTM

A short soluble form is also released from the membrane by proteolysis (PubMed:26876177). The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing (PubMed:26876177). mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3 (PubMed:26876177).

Koroknai, V., Szász, I., & Balázs, M. (2023). Association between IL11RA Overexpression and the Initiation of Melanoma Liver Metastasis.

He, F., Zhang, R., Kuraguchi, M., Zhao, L., & Yu, Z. (2023). In vivo efficacy of an anti-human IL11RA antibody in B-hIL11RA mice with APAP-induced liver damage. Cancer Research, 83(7_Supplement), 3993-3993.

Suzuki, S., Sasaki, K., Fukazawa, T., & Kubo, T. (2022). Xenopus laevis il11ra. L is an experimentally proven interleukin-11 receptor component that is required for tadpole tail regeneration. Scientific Reports, 12(1), 1903.

Topa, A., Rohlin, A., Andersson, M. K., Fehr, A., Lovmar, L., Stenman, G., & Kölby, L. (2022). The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis-IL11RA is an emerging core-gene for pansynostosis. European Journal of Medical Genetics, 65(5), 104476.

Nishimura, N., Murakami, H., Hayashi, T., Sato, H., & Kurosawa, K. (2020). Multiple craniosynostosis and facial dysmorphisms with homozygous IL11RA variant caused by maternal uniparental isodisomy of chromosome 9. Congenital Anomalies, 60(5), 153-155.

Korakavi, N., Prokop, J. W., & Seaver, L. H. (2019). Evolution of the phenotype of craniosynostosis with dental anomalies syndrome and report of IL11RA variant population frequencies in a Crouzon‐like autosomal recessive syndrome. American Journal of Medical Genetics Part A, 179(4), 668-673.

Brischoux‐Boucher, E., Trimouille, A., Baujat, G., Goldenberg, A., Schaefer, E., Guichard, B., ... & Van Maldergem, L. (2018). IL11RA‐related Crouzon‐like autosomal recessive craniosynostosis in 10 new patients: Resemblances and differences. Clinical Genetics, 94(3-4), 373-380.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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