Rabbit Anti-IL11RA Recombinant Antibody (EG1631) (CBMAB-EN1952-LY)

Name: Rabbit Anti-IL11RA Recombinant Antibody (EG1631)
SKU: CBMAB-EN1952-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1631

Application

WB: 1:500~1:3000 ELISA: 1:20000

Immunogen

The antibody was produced against synthesized peptide derived from C-terminal of human IL11RA.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 11 Receptor Subunit Alpha

Introduction

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Entrez Gene ID

3590

UniProt ID

Q14626

Alternative Names

Interleukin 11 Receptor Subunit Alpha

Function

Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.

Soluble interleukin-11 receptor subunit alpha:
Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177).

The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:30279168, PubMed:26876177).

Isoform HCR2:
Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177).

The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:30279168, PubMed:26876177).

Biological Process

Cytokine-mediated signaling pathway Source: GO_Central
Developmental process Source: UniProtKB
Head development Source: UniProtKB
Positive regulation of cell population proliferation Source: GO_Central

Cellular Location

Interleukin-11 receptor subunit alpha: Membrane
Soluble interleukin-11 receptor subunit alpha: Secreted
Isoform HCR2: Secreted

Involvement in disease

Craniosynostosis and dental anomalies (CRSDA):
A disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.

Topology

Extracellular: 24-370
Helical: 371-391
Cytoplasmic: 392-422

PTM

A short soluble form is also released from the membrane by proteolysis (PubMed:26876177). The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing (PubMed:26876177). mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3 (PubMed:26876177).

Koroknai, V., Szász, I., & Balázs, M. (2023). Association between IL11RA Overexpression and the Initiation of Melanoma Liver Metastasis.

He, F., Zhang, R., Kuraguchi, M., Zhao, L., & Yu, Z. (2023). In vivo efficacy of an anti-human IL11RA antibody in B-hIL11RA mice with APAP-induced liver damage. Cancer Research, 83(7_Supplement), 3993-3993.

Suzuki, S., Sasaki, K., Fukazawa, T., & Kubo, T. (2022). Xenopus laevis il11ra. L is an experimentally proven interleukin-11 receptor component that is required for tadpole tail regeneration. Scientific Reports, 12(1), 1903.

Topa, A., Rohlin, A., Andersson, M. K., Fehr, A., Lovmar, L., Stenman, G., & Kölby, L. (2022). The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis-IL11RA is an emerging core-gene for pansynostosis. European Journal of Medical Genetics, 65(5), 104476.

Nishimura, N., Murakami, H., Hayashi, T., Sato, H., & Kurosawa, K. (2020). Multiple craniosynostosis and facial dysmorphisms with homozygous IL11RA variant caused by maternal uniparental isodisomy of chromosome 9. Congenital Anomalies, 60(5), 153-155.

Korakavi, N., Prokop, J. W., & Seaver, L. H. (2019). Evolution of the phenotype of craniosynostosis with dental anomalies syndrome and report of IL11RA variant population frequencies in a Crouzon‐like autosomal recessive syndrome. American Journal of Medical Genetics Part A, 179(4), 668-673.

Brischoux‐Boucher, E., Trimouille, A., Baujat, G., Goldenberg, A., Schaefer, E., Guichard, B., ... & Van Maldergem, L. (2018). IL11RA‐related Crouzon‐like autosomal recessive craniosynostosis in 10 new patients: Resemblances and differences. Clinical Genetics, 94(3-4), 373-380.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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