Rat Recombinant IL11RA protein, His Tag (V2LY-0526-LY9436)

Name: Rat Recombinant IL11RA protein, His Tag
SKU: V2LY-0526-LY9436
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rat

Tag

His Tag

Protein Construction

This product is Rat Recombinant IL11RA protein, His Tag consist of Amino Acid: 1-366 and predicts a molecular mass of 39.1 kDa.

Molecule Mass

39.1 kDa

Sequence

Amino Acid: 1-366

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 11 Receptor Subunit Alpha

Function

Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.

Soluble interleukin-11 receptor subunit alpha:
Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177).

The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:30279168, PubMed:26876177).

Isoform HCR2:
Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:30279168, PubMed:26876177).

The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:30279168, PubMed:26876177).

Biological Process

Cytokine-mediated signaling pathway Source: GO_Central
Developmental process Source: UniProtKB
Head development Source: UniProtKB
Positive regulation of cell population proliferation Source: GO_Central

Cellular Location

Interleukin-11 receptor subunit alpha: Membrane
Soluble interleukin-11 receptor subunit alpha: Secreted
Isoform HCR2: Secreted

Involvement in disease

Craniosynostosis and dental anomalies (CRSDA):
A disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.

Topology

Extracellular: 24-370
Helical: 371-391
Cytoplasmic: 392-422

PTM

A short soluble form is also released from the membrane by proteolysis (PubMed:26876177). The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing (PubMed:26876177). mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3 (PubMed:26876177).

Koroknai, V., Szász, I., & Balázs, M. (2023). Association between IL11RA Overexpression and the Initiation of Melanoma Liver Metastasis.

He, F., Zhang, R., Kuraguchi, M., Zhao, L., & Yu, Z. (2023). In vivo efficacy of an anti-human IL11RA antibody in B-hIL11RA mice with APAP-induced liver damage. Cancer Research, 83(7_Supplement), 3993-3993.

Suzuki, S., Sasaki, K., Fukazawa, T., & Kubo, T. (2022). Xenopus laevis il11ra. L is an experimentally proven interleukin-11 receptor component that is required for tadpole tail regeneration. Scientific Reports, 12(1), 1903.

Topa, A., Rohlin, A., Andersson, M. K., Fehr, A., Lovmar, L., Stenman, G., & Kölby, L. (2022). The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis-IL11RA is an emerging core-gene for pansynostosis. European Journal of Medical Genetics, 65(5), 104476.

Nishimura, N., Murakami, H., Hayashi, T., Sato, H., & Kurosawa, K. (2020). Multiple craniosynostosis and facial dysmorphisms with homozygous IL11RA variant caused by maternal uniparental isodisomy of chromosome 9. Congenital Anomalies, 60(5), 153-155.

Korakavi, N., Prokop, J. W., & Seaver, L. H. (2019). Evolution of the phenotype of craniosynostosis with dental anomalies syndrome and report of IL11RA variant population frequencies in a Crouzon‐like autosomal recessive syndrome. American Journal of Medical Genetics Part A, 179(4), 668-673.

Brischoux‐Boucher, E., Trimouille, A., Baujat, G., Goldenberg, A., Schaefer, E., Guichard, B., ... & Van Maldergem, L. (2018). IL11RA‐related Crouzon‐like autosomal recessive craniosynostosis in 10 new patients: Resemblances and differences. Clinical Genetics, 94(3-4), 373-380.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL11RA protein, His Tag (CAT#: V2LY-0526-LY4722)

Mouse Recombinant IL11RA protein, His Tag (CAT#: V2LY-0526-LY8464)

Canine Recombinant IL-11RA protein (CAT#: V2LY-0526-LY1264)

Canine Recombinant IL-11RA protein, hFc Tag (CAT#: V2LY-0526-LY1265)

Canine Recombinant IL-11RA protein, His Tag (CAT#: V2LY-0526-LY1266)

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Mouse Recombinant IL11RA protein, His Tag (CAT#: V2LY-0526-LY8464)

Mouse Anti-IL11RA Recombinant Antibody (2D4-F4) (CAT#: CBMAB-I0369-YY)

Canine Recombinant IL-11RA protein, hFc Tag (CAT#: V2LY-0526-LY1265)

Canine Recombinant IL-11RA protein, His Tag (CAT#: V2LY-0526-LY1266)

Mouse Anti-IL11RA Recombinant Antibody (3D4-G4) (CAT#: CBMAB-A4325-LY)

Canine Recombinant IL-11RA protein (CAT#: V2LY-0526-LY1264)

Human Recombinant IL11RA protein, His Tag (CAT#: V2LY-0526-LY4722)

Isotype control

For research use only. Not intended for any clinical use.

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