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Mouse Anti-IL16 Recombinant Antibody (70720) (CBMAB-I1603-YY)

This product is Mouse antibody that recognizes IL16. The antibody 70720 can be used for immunoassay techniques such as: ICFC
See all IL16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
70720
Antibody Isotype
IgG2b
Application
ICFC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 16
Introduction
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
3603
UniProt ID
Q14005
Alternative Names
Interleukin 16
Function
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.

Isoform 1:
May act as a scaffolding protein that anchors ion channels in the membrane.

Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Biological Process
Cytokine-mediated signaling pathway Source: ARUK-UCL
Immune response Source: ProtInc
Induction of positive chemotaxis Source: GO_Central
Leukocyte chemotaxis Source: GO_Central
Positive regulation of inflammatory response Source: ARUK-UCL
Positive regulation of interleukin-12 production Source: ARUK-UCL
Positive regulation of interleukin-1 alpha production Source: ARUK-UCL
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of neutrophil activation Source: ARUK-UCL
Regulation of calcium ion transport Source: CAFA
Cellular Location
Interleukin-16: Secreted
Isoform 1: Cytoplasm
Isoform 3: Nucleus; Cytoplasm
PTM
Isoform 3:
Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16.

Ma, C., Zhou, Y., Yi, W., Zhou, X., Guo, W., Xu, X., ... & Chen, D. (2022). Electroacupuncture of the Baihui and Shenting acupoints for vascular dementia in rats through the miR-81/IL-16/PSD-95 pathway. Annals of Translational Medicine, 10(10).

Ramirez, J., Bitterman, P., Basu, S., & Barua, A. (2022). Changes in IL-16 expression in the ovary during aging and its potential consequences to ovarian pathology. Journal of immunology research, 2022.

Liu, Y., Ma, X., & Liu, Y. (2021). Hsa_circ_0001326 regulates proliferation, migration, invasion, and EMT of HTR‐8/SVneo cells via increasing IL16 expression. American Journal of Reproductive Immunology, 86(5), e13484.

Wang, D., & Han, L. (2021). Downregulation of miR‑1184 serves as a diagnostic biomarker in neonatal sepsis and regulates LPS‑induced inflammatory response by inhibiting IL‑16 in monocytes. Experimental and therapeutic medicine, 21(4), 1-1.

Kawabata, K., Makino, T., Makino, K., Kajihara, I., Fukushima, S., & Ihn, H. (2020). IL-16 expression is increased in the skin and sera of patients with systemic sclerosis. Rheumatology, 59(3), 519-523.

Ahmad, S. F., Ansari, M. A., Nadeem, A., Bakheet, S. A., Al-Ayadhi, L. Y., & Attia, S. M. (2019). Elevated IL-16 expression is associated with development of immune dysfunction in children with autism. Psychopharmacology, 236, 831-838.

Huang, Y., Du, K. L., Guo, P. Y., Zhao, R. M., Wang, B., Zhao, X. L., & Zhang, C. Q. (2019). IL-16 regulates macrophage polarization as a target gene of mir-145-3p. Molecular Immunology, 107, 1-9.

Cheng, F., Liu, L., Zhang, H., Zhu, Y., Li, X., & Li, H. (2019). Association of IL-16 gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population. Bioscience Reports, 39(8), BSR20190821.

Smith, S., Wu, P. W., Seo, J. J., Fernando, T., Jin, M., Contreras, J., ... & Jefferies, C. A. (2018). IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation. JCI insight, 3(15).

Matalliotakis, M., Zervou, M. I., Eliopoulos, E., Matalliotaki, C., Rahmioglu, N., Kalogiannidis, I., ... & Goulielmos, G. N. (2018). The role of IL‑16 gene polymorphisms in endometriosis. international journal of molecular medicine, 41(3), 1469-1476.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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