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IL16

The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Full Name

Interleukin 16

Function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.

Isoform 1:
May act as a scaffolding protein that anchors ion channels in the membrane.

Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Biological Process

Cytokine-mediated signaling pathway Source: ARUK-UCL
Immune response Source: ProtInc
Induction of positive chemotaxis Source: GO_Central
Leukocyte chemotaxis Source: GO_Central
Positive regulation of inflammatory response Source: ARUK-UCL
Positive regulation of interleukin-12 production Source: ARUK-UCL
Positive regulation of interleukin-1 alpha production Source: ARUK-UCL
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of neutrophil activation Source: ARUK-UCL
Regulation of calcium ion transport Source: CAFA

Cellular Location

Interleukin-16: Secreted
Isoform 1: Cytoplasm
Isoform 3: Nucleus; Cytoplasm

PTM

Isoform 3:
Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16.

Anti-IL16 antibodies

Mouse Anti-IL16 Recombinant Antibody (CBYY-I1445) (CBMAB-I2615-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-I1445

Application*: E, WB

Mouse Anti-IL16 Recombinant Antibody (CBYY-I1267) (CBMAB-I2436-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1267

Application*: WB

Rabbit Anti-IL16 Recombinant Antibody (CBYY-I0974) (CBMAB-I2142-YY)

SDS

Target: IL16

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-I0974

Application*: P

Mouse Anti-IL16 Recombinant Antibody (70720) (CBMAB-I1603-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 70720

Application*: IS

Mouse Anti-IL16 Recombinant Antibody (CBYY-I0718) (CBMAB-I1602-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0718

Application*: WB, EC

Mouse Anti-IL16 Recombinant Antibody (5D8) (CBMAB-I1438-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5D8

Application*: E, WB, P, IF, F

Mouse Anti-IL16 Recombinant Antibody (59) (CBMAB-I1409-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 59

Application*: E, WB

Mouse Anti-IL16 Recombinant Antibody (572) (CBMAB-I1401-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 572

Application*: E, WB

Mouse Anti-IL16 Recombinant Antibody (568) (CBMAB-I1400-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 568

Application*: E, WB

Mouse Anti-IL16 Recombinant Antibody (210) (CBMAB-I0404-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 210

Application*: E

Mouse Anti-IL16 Recombinant Antibody (17.1) (CBMAB-I0403-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 17.1

Application*: E, WB

Mouse Anti-IL16 Recombinant Antibody (14.1) (CBMAB-I0402-YY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 14.1

Application*: IS, E, IH, BL

Mouse Anti-IL16 Recombinant Antibody (A473) (CBMAB-AP3735LY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: A473

Application*: Dot blot, ELISA, WB

Mouse Anti-IL16 Recombinant Antibody (A472) (CBMAB-AP10837LY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: A472

Application*: ELISA, WB

Mouse Anti-IL16 Recombinant Antibody (CF221) (CBMAB-FT252LY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CF221

Application*: ELISA, WB

Mouse Anti-IL16 Monoclonal Antibody (CBFYR0223) (CBMAB-R0223-FY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYR0223

Application*: E

Mouse Anti-IL16 Monoclonal Antibody (CBFYR0222) (CBMAB-R0222-FY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: CBFYR0222

Application*: E, WB

Mouse Anti-IL16 Monoclonal Antibody (CBFYR0221) (CBMAB-R0221-FY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYR0221

Application*: E, WB

Mouse Anti-IL16 Monoclonal Antibody (CBFYR0220) (CBMAB-R0220-FY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYR0220

Application*: E

Mouse Anti-IL16 Monoclonal Antibody (CBFYR0219) (CBMAB-R0219-FY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYR0219

Application*: E, WB

Mouse Anti-IL16 Monoclonal Antibody (CBFYR0218) (CBMAB-R0218-FY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYR0218

Application*: E

Mouse Anti-IL16 Monoclonal Antibody (CBFYR0217) (CBMAB-R0217-FY)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYR0217

Application*: WB

Mouse Anti-IL16 Recombinant Antibody (CBYCL-126) (CBMAB-L0027-YC)

SDS

Target: IL16

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCL-126

Application*: WB, IC, P, C, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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