Mouse Recombinant IL16 protein, His Tag (V2LY-0526-LY8487)

Name: Mouse Recombinant IL16 protein, His Tag
SKU: V2LY-0526-LY8487
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant IL16 protein, His Tag consist of Amino Acid: 1205-1322 and predicts a molecular mass of 14.5 kDa.

Molecule Mass

14.5 kDa

Sequence

Amino Acid: 1205-1322

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile His, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 16

Function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.

Isoform 1:
May act as a scaffolding protein that anchors ion channels in the membrane.

Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Biological Process

Cytokine-mediated signaling pathway Source: ARUK-UCL
Immune response Source: ProtInc
Induction of positive chemotaxis Source: GO_Central
Leukocyte chemotaxis Source: GO_Central
Positive regulation of inflammatory response Source: ARUK-UCL
Positive regulation of interleukin-12 production Source: ARUK-UCL
Positive regulation of interleukin-1 alpha production Source: ARUK-UCL
Positive regulation of interleukin-6 production Source: ARUK-UCL
Positive regulation of neutrophil activation Source: ARUK-UCL
Regulation of calcium ion transport Source: CAFA

Cellular Location

Interleukin-16: Secreted
Isoform 1: Cytoplasm
Isoform 3: Nucleus; Cytoplasm

PTM

Isoform 3:
Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16.

Ma, C., Zhou, Y., Yi, W., Zhou, X., Guo, W., Xu, X., ... & Chen, D. (2022). Electroacupuncture of the Baihui and Shenting acupoints for vascular dementia in rats through the miR-81/IL-16/PSD-95 pathway. Annals of Translational Medicine, 10(10).

Ramirez, J., Bitterman, P., Basu, S., & Barua, A. (2022). Changes in IL-16 expression in the ovary during aging and its potential consequences to ovarian pathology. Journal of immunology research, 2022.

Liu, Y., Ma, X., & Liu, Y. (2021). Hsa_circ_0001326 regulates proliferation, migration, invasion, and EMT of HTR‐8/SVneo cells via increasing IL16 expression. American Journal of Reproductive Immunology, 86(5), e13484.

Wang, D., & Han, L. (2021). Downregulation of miR‑1184 serves as a diagnostic biomarker in neonatal sepsis and regulates LPS‑induced inflammatory response by inhibiting IL‑16 in monocytes. Experimental and therapeutic medicine, 21(4), 1-1.

Kawabata, K., Makino, T., Makino, K., Kajihara, I., Fukushima, S., & Ihn, H. (2020). IL-16 expression is increased in the skin and sera of patients with systemic sclerosis. Rheumatology, 59(3), 519-523.

Ahmad, S. F., Ansari, M. A., Nadeem, A., Bakheet, S. A., Al-Ayadhi, L. Y., & Attia, S. M. (2019). Elevated IL-16 expression is associated with development of immune dysfunction in children with autism. Psychopharmacology, 236, 831-838.

Huang, Y., Du, K. L., Guo, P. Y., Zhao, R. M., Wang, B., Zhao, X. L., & Zhang, C. Q. (2019). IL-16 regulates macrophage polarization as a target gene of mir-145-3p. Molecular Immunology, 107, 1-9.

Cheng, F., Liu, L., Zhang, H., Zhu, Y., Li, X., & Li, H. (2019). Association of IL-16 gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population. Bioscience Reports, 39(8), BSR20190821.

Smith, S., Wu, P. W., Seo, J. J., Fernando, T., Jin, M., Contreras, J., ... & Jefferies, C. A. (2018). IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation. JCI insight, 3(15).

Matalliotakis, M., Zervou, M. I., Eliopoulos, E., Matalliotaki, C., Rahmioglu, N., Kalogiannidis, I., ... & Goulielmos, G. N. (2018). The role of IL‑16 gene polymorphisms in endometriosis. international journal of molecular medicine, 41(3), 1469-1476.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL16 protein, His Tag (CAT#: V2LY-0526-LY4763)

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Isotype control

For research use only. Not intended for any clinical use.

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