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Rat Anti-IL17RB Recombinant Antibody (152309) (CBMAB-I0426-YY)

This product is Rat antibody that recognizes IL17RB. The antibody 152309 can be used for immunoassay techniques such as: WB, ELISA
See all IL17RB antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
152309
Antibody Isotype
IgG2a
Application
WB, ELISA

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
0.2 μm filtered solution in with Trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 17 Receptor B
Introduction
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.
Entrez Gene ID
50905
UniProt ID
Q9JIP3
Alternative Names
Interleukin 17 Receptor B
Function
Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
Biological Process
Defense response Source: ProtInc
Regulation of cell growth Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Topology
Extracellular: 18-292
Helical: 293-313
Cytoplasmic: 314-502

Yuan, S. S. F., Su, C. W., Chan, L. P., Nguyen, H. D., Chen, Y. K., Du, J. K., ... & Wang, Y. Y. (2023). IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer. Oral Diseases.

Sun, Y., Khan, M. A. A. K., Mangiola, S., & Barrow, A. D. (2023). IL17RB and IL17REL Expression Are Associated with Improved Prognosis in HPV-Infected Head and Neck Squamous Cell Carcinomas. Pathogens, 12(4), 572.

Boyraz, B., Kirkpatrick, G., Kaluziak, S. T., Morris, R., Kreuzer, J., Haas, W., ... & Sgroi, D. (2023). Abstract P2-03-05: HOXB13/IL17RB-low breast cancers are predicted to respond to PIK3CA inhibitors independent of PIK3CA mutational status. Cancer Research, 83(5_Supplement), P2-03.

Bing, N., Zhou, H., Chen, X., Hirose, T., Kochi, Y., Tsuchida, Y., ... & Clark, J. D. (2021). Contribution of a european‐prevalent variant near CD83 and an east asian–prevalent variant near IL17RB to herpes zoster risk in tofacitinib treatment: results of genome‐wide association study meta‐analyses. Arthritis & rheumatology, 73(7), 1155-1166.

Todorović-Raković, N., Milovanović, J., Greenman, J., & Radulovic, M. (2021). The significance of HOXB7 and IL17RB serum levels in prognosis of hormonally dependent breast cancer: A pilot study. Advances in Medical Sciences, 66(2), 359-365.

Hu, O., Provvido, A., & Zhu, Y. (2020). Generation of IL17RB Knockout Cell Lines Using CRISPR/Cas9-Based Genome Editing. Immune Mediators in Cancer: Methods and Protocols, 345-353.

Song, Y., Ji, B., Jiang, C. X., Chen, Z. M., Yao, N. H., Mukaida, N., & Huang, H. (2019). IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer. Pathology-Research and Practice, 215(12), 152650.

Goto, N., Fukuda, A., Yamaga, Y., Yoshikawa, T., Maruno, T., Maekawa, H., ... & Seno, H. (2019). Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells. Proceedings of the National Academy of Sciences, 116(26), 12996-13005.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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