IL17RB
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.
Full Name
Interleukin 17 Receptor B
Function
Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
Biological Process
Defense response Source: ProtInc
Regulation of cell growth Source: UniProtKB
Regulation of cell growth Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 2: Secreted
Topology
Extracellular: 18-292
Helical: 293-313
Cytoplasmic: 314-502
Helical: 293-313
Cytoplasmic: 314-502
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Anti-IL17RB antibodies
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CompareTarget: IL17RB
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I1560
Application*: F
Target: IL17RB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1320
Application*: E, WB
Target: IL17RB
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1094
Application*: F, WB
Target: IL17RB
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 9J28
Application*: WB
Target: IL17RB
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I0822
Application*: F
Target: IL17RB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 97C691
Application*: WB, IH
Target: IL17RB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0816
Application*: WB, F
Target: IL17RB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0815
Application*: F, MC
Target: IL17RB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0814
Application*: IH, P, IC
Target: IL17RB
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 752101
Application*: F, MC
Target: IL17RB
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-I0703
Application*: F
Target: IL17RB
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I0365
Application*: F
Target: IL17RB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0339
Application*: WB
Target: IL17RB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0152
Application*: WB, ED, MC, F
Target: IL17RB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0151
Application*: WB, E
Target: IL17RB
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 152316
Application*: WB
Target: IL17RB
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 152309
Application*: WB, E
Target: IL17RB
Sensitivity: 0.17 pg/mL
Detection Range: 0.3-90 pg/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: IL17RB
Sensitivity: 0.024 ng/mL
Detection Range: 0.05-15 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: IL17RB
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-288
Tag: hFc Tag
Target: IL17RB
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-288
Tag: His Tag
Target: IL17RB
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-286
Tag: His Tag
Target: IL17RB
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-286
Tag: hFc Tag
Target: IL17RB
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-289
Tag: His Tag
Target: IL17RB
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-289
Tag: hFc Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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