Human IL17RB ELISA Kit (V2LY-0626-LY3933)

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Tested Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.024 ng/mL
Detection Range
0.05-15 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
55.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Interleukin 17 Receptor B
Function
Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
Biological Process
Defense response Source: ProtInc
Regulation of cell growth Source: UniProtKB
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Topology
Extracellular: 18-292
Helical: 293-313
Cytoplasmic: 314-502

Yuan, S. S. F., Su, C. W., Chan, L. P., Nguyen, H. D., Chen, Y. K., Du, J. K., ... & Wang, Y. Y. (2023). IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer. Oral Diseases.

Sun, Y., Khan, M. A. A. K., Mangiola, S., & Barrow, A. D. (2023). IL17RB and IL17REL Expression Are Associated with Improved Prognosis in HPV-Infected Head and Neck Squamous Cell Carcinomas. Pathogens, 12(4), 572.

Boyraz, B., Kirkpatrick, G., Kaluziak, S. T., Morris, R., Kreuzer, J., Haas, W., ... & Sgroi, D. (2023). Abstract P2-03-05: HOXB13/IL17RB-low breast cancers are predicted to respond to PIK3CA inhibitors independent of PIK3CA mutational status. Cancer Research, 83(5_Supplement), P2-03.

Bing, N., Zhou, H., Chen, X., Hirose, T., Kochi, Y., Tsuchida, Y., ... & Clark, J. D. (2021). Contribution of a european‐prevalent variant near CD83 and an east asian–prevalent variant near IL17RB to herpes zoster risk in tofacitinib treatment: results of genome‐wide association study meta‐analyses. Arthritis & rheumatology, 73(7), 1155-1166.

Todorović-Raković, N., Milovanović, J., Greenman, J., & Radulovic, M. (2021). The significance of HOXB7 and IL17RB serum levels in prognosis of hormonally dependent breast cancer: A pilot study. Advances in Medical Sciences, 66(2), 359-365.

Hu, O., Provvido, A., & Zhu, Y. (2020). Generation of IL17RB Knockout Cell Lines Using CRISPR/Cas9-Based Genome Editing. Immune Mediators in Cancer: Methods and Protocols, 345-353.

Song, Y., Ji, B., Jiang, C. X., Chen, Z. M., Yao, N. H., Mukaida, N., & Huang, H. (2019). IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer. Pathology-Research and Practice, 215(12), 152650.

Goto, N., Fukuda, A., Yamaga, Y., Yoshikawa, T., Maruno, T., Maekawa, H., ... & Seno, H. (2019). Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells. Proceedings of the National Academy of Sciences, 116(26), 12996-13005.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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